2017-12-01Author:adminpraise:0
TNF (Tumor Necrosis Factor) encodes a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor superfamily. It is mainly secreted by macrophages and can induce cell death in certain tumor cell lines. This protein can act by binding to its receptors TNFRSF1A / TNFR1 and TNFRSF1B / TNFBR. This cytokine is involved in the regulation of a wide range of biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. It involves a variety of diseases, including autoimmune diseases, insulin resistance, migraine, asthma and cancer. Studies in TNF knockout mice have also shown that this cytokine has neuroprotective properties. Its related pathways are the hematopoietic cell line and the cytokine receptor gamma-chain family signaling pathways.
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Human |
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Mouse |
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Rat |
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Human, Mouse, Rat |
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Mouse |
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Human, Mouse, Rat |
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Human |
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Human, Mouse, Rat, Monkey |
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Human |
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Human, Mouse, Rat |
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Human, Mouse, Rat |
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Mouse |
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Mouse |