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Rat IL-6(Interleukin 6) ELISA Kit

Citations(477)Uniprot : P20607

  • Cat.No.:E-EL-R0015

  • Reactivity: Rat
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Manual MSDS

To Purchase E-EL-R0015

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 12.50-800 pg/mL
Sensitivity 7.50 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat IL-6 in samples. No significant cross-reactivity or interference between Rat IL-6 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat IL-6 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-6. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat IL-6 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat IL-6. You can calculate the concentration of Rat IL-6 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat IL-6 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat IL-6 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 34.58 93.20 396.79 34.39 95.73 379.80
Standard deviation 2.04 4.50 19.96 1.75 4.79 18.61
CV (%) 5.90 4.83 5.03 5.09 5.00 4.90

Recovery

The recovery of Rat IL-6 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 98-111 105
EDTA plasma (n=8) 95-109 102
Cell culture media (n=8) 89-95 92

Linearity

Samples were spiked with high concentrations of Rat IL-6 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P20607
SynonymsIL6, BSF2, HGF, HSF, IFNB2, CDF
Research AreaCancer, Metabolism, Immunology, Neuroscience

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. CRITICAL CARE (2022) IF: 19.334
    Individualizing mechanical ventilation: titration of driving pressure to pulmonary elastance through Young’s modulus in an acute respiratory distress syndrome animal model

    DOI: 10.1186/s13054-022-04184-w

    PMID: 36258235

    		 Sample: bronchoalveolar lavages (BAL)
  2. CARDIOVASCULAR RESEARCH (2022) IF: 13.081
    Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

    DOI: 10.1093/cvr/cvac181
    Sample: CD4+ T cells
  3. BIOMATERIALS (2021) IF: 12.479
    Polyphenol-assisted facile assembly of bioactive nanoparticles for targeted therapy of heart diseases

    DOI: 10.1016/j.biomaterials.2021.120952

    PMID: 34147720

    		 Sample: heart
  4. Applied Materials Today (2022) IF: 10.041
    Preclinical studies of an automated radiolabeled microcarriers for radiosynovectomy of inflammatory joint disease

    DOI: 10.1016/j.apmt.2022.101571
    Sample: Serum
  5. JOURNAL OF NANOBIOTECHNOLOGY (2022) IF: 10.435
    A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation

    DOI: 10.1186/s12951-022-01277-0

    PMID: 35123501

    		 Sample: rat bone marrow mesenchymal stem cells (rBMSCs)
  6. ACS Applied Materials & Interfaces (2021) IF: 9.2289
    Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase

    DOI: 10.1021/acsami.1c03589

    PMID: 33764751

    		 Sample: Plasma
  7. Journal of Neuroinflammation (2023) IF: 9.587
    Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

    DOI: 10.1186/s12974-023-02715-y
    Sample: brain,serum
  8. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 8.025
    Structural elucidation and anti-neuroinflammatory activity of Polygala tenuifolia polysaccharide

    DOI: 10.1016/j.ijbiomac.2022.08.161

    PMID: 36037912

    		 Sample: serum
  9. Stem Cell Research & Therapy (2022) IF: 8.0790
    Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome

    DOI: 10.1186/s13287-022-03000-0

    PMID: 35841081

    		 Sample: serum
  10. AMERICAN JOURNAL OF TRANSPLANTATION (2022) IF: 8.086
    Machine perfusion combined with antibiotics prevents donor-derived infections caused by multidrug-resistant bacteria

    DOI: 10.1111/ajt.17032

    PMID: 35303398

    		 Sample: serum
  11. Journal of Neuroinflammation (2021) IF: 8.3219
    EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model

    DOI: 10.1186/s12974-021-02255-3

    PMID: 34530836

    		 Sample: brain
  12. Frontiers in Immunology (2022) IF: 8.786
    Dynamic Monitoring of Immunoinflammatory Response Identifies Immunoswitching Characteristics of Severe Acute Pancreatitis in Rats

    DOI: 10.3389/fimmu.2022.876168
    Sample: serum
  13. International Journal of Nanomedicine (2023) IF: 7.033
    Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

    DOI: 10.2147/IJN.S394544
    Sample: blood
  14. Oxidative Medicine and Cellular Longevity (2023) IF: 7.31
    Ferroptosis in Rat Lung Tissue during Severe Acute Pancreatitis-Associated Acute Lung Injury: Protection of Qingyi Decoction

    DOI: 10.1155/2023/5827613
    Sample: serum
  15. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury

    DOI: 10.1155/2022/3576892

    PMID: 35855864

    		 Sample: serum
  16. BIOMEDICINE & PHARMACOTHERAPY (2023) IF: 7.419
    Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

    DOI: 10.1016/j.biopha.2023.114330
    Sample: serum
  17. Antioxidants (2022) IF: 7.675
    Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson’s Disease

    DOI: 10.3390/antiox11122396
    Sample: plasma
  18. Antioxidants (2022) IF: 7.675
    Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain

    DOI: 10.3390/antiox11112154

    PMID: 36358526

    		 Sample: brain tissue
  19. JOURNAL OF CONTROLLED RELEASE (2020) IF: 7.727
    Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy

    DOI: 10.1016/j.jconrel.2020.12.036

    PMID: 33359582

    		 Sample: glioma cell lysate
  20. Frontiers in Cardiovascular Medicine (2021) IF: 6.05
    Long Non-coding RNA N1LR Protects Against Myocardial Ischemic/Reperfusion Injury Through Regulating the TGF-β Signaling Pathway

    DOI: 10.3389/fcvm.2021.654969

    PMID: 34485393

    		 Sample: H9c2 cell
  21. Journal of Ginseng Research (2021) IF: 6.06
    Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2

    DOI: 10.1016/j.jgr.2021.02.001

    PMID: 34803427

    		 Sample: Serum
  22. Frontiers in Cellular and Infection Microbiology (2022) IF: 6.073
    Liujunanwei decoction attenuates cisplatin-induced nausea and vomiting in a Rat-Pica model partially mediated by modulating the gut micsrobiome

    DOI: 10.3389/fcimb.2022.876781

    PMID: 36061858

    		 Sample: jejunum tissue,medulla oblongata tissue
  23. Frontiers in Cellular and Infection Microbiology (2022) IF: 6.073
    Changes in intestinal microflora and its metabolites underlie the cognitive impairment in preterm rats

    DOI: 10.3389/fcimb.2022.945851

    PMID: 36061856

    		 Sample: serum
  24. BRAIN BEHAVIOR AND IMMUNITY (2019) IF: 6.17
    High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats

    DOI: 10.1016/j.bbi.2019.08.007
    Sample: plasma，brain
  25. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
    Ameliorative Effects of a Rhenium (V) Compound with Uracil-Derived Ligand Markers Associated with Hyperglycaemia-Induced Renal Dysfunction in Diet-Induced Prediabetic Rats

    DOI: 10.3390/ijms232315400
    Sample: kidney
  26. Arabian Journal of Chemistry (2022) IF: 6.212
    Calotropis procera (Aiton) seeds fixed oil: Physicochemical analysis, GC-MS profiling and evaluation of its in-vivo anti-inflammatory and in-vitro antiparasitic activities

    DOI: 10.1016/j.arabjc.2022.104085
    Sample: Serum
  27. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019) IF: 6.291
    Soybean isoflavones prevent atrazine-induced neurodegenerative damage by inducing autophagy

    DOI: 10.1016/j.ecoenv.2019.110065

    PMID: 31869719

    		 Sample: Tissue homogenate
  28. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291
    Effects of cadmium on organ function, gut microbiota and its metabolomics profile in adolescent rats

    DOI: 10.1016/j.ecoenv.2021.112501

    PMID: 34265528

    		 Sample: serum
  29. Antioxidants (2020) IF: 6.313
    Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats

    DOI: 10.3390/antiox9111073

    PMID: 33142857

    		 Sample: Plasma
  30. Antioxidants (2022) IF: 6.313
    Cisplatin-Induced Reproductive Toxicity and Oxidative Stress: Ameliorative Effect of Kinetin

    DOI: 10.3390/antiox11050863

    PMID: 35624727

    		 Sample: testicular tissue
  31. Pharmaceutics (2022) IF: 6.321
    Reparative Efficacy of Liposome-Encapsulated Oleanolic Acid against Liver Inflammation Induced by Fine Ambient Particulate Matter and Alcohol in Mice

    DOI: 10.3390/pharmaceutics14051108

    PMID: 35631694

    		 Sample: LX-2 cell
  32. MOLECULAR MEDICINE (2023) IF: 6.376
    Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis

    DOI: 10.1186/s10020-023-00614-9
    Sample: Serum
  33. Pharmaceutics (2023) IF: 6.525
    Immunomodulatory Effect of Novel Electrospun Nanofibers Loaded with Doxycycline as an Adjuvant Treatment in Periodontitis

    DOI: 10.3390/pharmaceutics15020707
    Sample: Blood
  34. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Water-soluble alkaloids extracted from Aconiti Radix lateralis praeparata protect against chronic heart failure in rats via a calcium signaling pathway

    DOI: 10.1016/j.biopha.2020.111184

    PMID: 33418305

    		 Sample: Plasma
  35. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 6.53
    Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway

    DOI: 10.1016/j.biopha.2020.110273

    PMID: 32460188

    		 Sample: Cell culture supernatant
  36. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Lipoic acid (LA) dose-dependently protects bone losses in the mandible of rats during the development of osteopenia by inhibiting oxidative stress and promoting bone formation

    DOI: 10.1016/j.biopha.2021.112467

    PMID: 34891114

    		 Sample: serum
  37. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats

    DOI: 10.1016/j.biopha.2022.112948

    PMID: 35430394

    		 Sample: skin tissue
  38. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats

    DOI: 10.1016/j.biopha.2021.111760

    PMID: 34052566

    		 Sample: Tissue homogenate,Plasma
  39. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    Excesive consumption of unsaturated fatty acids leads to oxidative and inflammatory instability in Wistar rats

    DOI: 10.1016/j.biopha.2021.111691

    PMID: 34243613

    		 Sample: Tissue homogenate(Liver)
  40. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats

    DOI: 10.1016/j.biopha.2022.112870

    PMID: 35367769

    		 Sample: serum
  41. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    Potential Therapeutic Effects of Mi-Jian-Chang-Pu Decoction on Neurochemical and Metabolic Changes of Cerebral Ischemia-Reperfusion Injury in Rats

    DOI: 10.1155/2022/7319563

    PMID: 35578728

    		 Sample: brain
  42. Frontiers in Nutrition (2022) IF: 6.576
    Comparative Analysis of the Bioactive Compounds in Chicken Cartilage: Protective Effects of Chondroitin Sulfate and Type II Collagen Peptides Against Osteoarthritis Involve Gut Microbiota

    DOI: 10.3389/fnut.2022.843360
    Sample: synovial fluid,serum
  43. Cells (2019) IF: 6.6
    Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways

    DOI: 10.3390/cells8070739
    Sample: PC12 cells
  44. PHYTOMEDICINE (2022) IF: 6.656
    Integration of transdermal chemistry and network pharmacology to decipher the mechanism of ShexiangZhuifeng analgesic plaster to treat rheumatoid arthritis

    DOI: 10.1016/j.phymed.2022.154507

    PMID: 36334391

    		 Sample: serum
  45. PHYTOMEDICINE (2022) IF: 6.656
    A discovery of clinically approved Panlongqi Tablet for repositioning to treat osteoarthritis by inhibiting PI3K/AKT activation

    DOI: 10.1016/j.phymed.2022.154360
    Sample: serum
  46. Nutrients (2022) IF: 6.706
    Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway

    DOI: 10.3390/nu14153247
    Sample: serum
  47. Nutrients (2022) IF: 6.706
    Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes

    DOI: 10.3390/nu14153179
    Sample: C6 cell
  48. Nutrients (2022) IF: 6.706
    Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats

    DOI: 10.3390/nu14214665
    Sample: serum
  49. LIFE SCIENCES (2022) IF: 6.78
    Nephroprotective potential of eugenol in a rat experimental model of chronic kidney injury; targeting NOX, TGF-β, and Akt signaling

    DOI: 10.1016/j.lfs.2022.120957

    PMID: 36113730

    		 Sample: serum
  50. LIFE SCIENCES (2022) IF: 6.78
    Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways

    DOI: 10.1016/j.lfs.2022.121152
    Sample: testis
  51. BRITISH JOURNAL OF PHARMACOLOGY (2018) IF: 6.81
    High‐fructose corn syrup consumption in adolescent rats causes bipolar‐like behavioural phenotype with hyperexcitability in hippocampal CA3‐CA1 synapses

    DOI: 10.1111/bph.14500
    Sample: Serum
  52. Journal of Inflammation Research (2021) IF: 6.922
    Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model

    DOI: 10.2147/JIR.S338973
    Sample: serum
  53. Journal of Inflammation Research (2021) IF: 6.922
    Anti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats

    DOI: 10.2147/JIR.S304076
    Sample: serum
  54. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 6.953
    Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats

    DOI: 10.1016/j.ijbiomac.2022.04.029

    PMID: 35398386

    		 Sample: prostate
  55. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
    Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation

    DOI: 10.1016/j.ijbiomac.2021.05.066

    PMID: 33992651

    		 Sample: Tissue homogenate(Liver)
  56. BIOMACROMOLECULES (2021) IF: 6.988
    Fabrication of In Situ Layered Hydrogel Scaffold for the Co-delivery of PGDF-BB/Chlorhexidine to Regulate Proinflammatory Cytokines, Growth Factors, and MMP-9 in a Diabetic Skin Defect Albino Rat Model

    DOI: 10.1021/acs.biomac.0c01709

    PMID: 33899465

    		 Sample: Tissue homogenate,Serum
  57. LIFE SCIENCES (2021) IF: 5.037
    Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: Novel mechanistic insight

    DOI: 10.1016/j.lfs.2021.119433

    PMID: 33794250

    		 Sample: Serum
  58. LIFE SCIENCES (2021) IF: 5.037
    Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats

    DOI: 10.1016/j.lfs.2021.119957

    PMID: 34530017

    		 Sample: Breast tissue
  59. LIFE SCIENCES (2021) IF: 5.037
    Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats

    DOI: 10.1016/j.lfs.2021.119638

    PMID: 34051216

    		 Sample: Tissue homogenate,Serum
  60. LIFE SCIENCES (2021) IF: 5.037
    Arjunolic acid downregulates elevated blood sugar and pro-inflammatory cytokines in streptozotocin (STZ)-nicotinamide induced type 2 diabetic rats

    DOI: 10.1016/j.lfs.2021.120232

    PMID: 34919901

    		 Sample: serum,pancreatic tissue
  61. Oxidative Medicine and Cellular Longevity (2020) IF: 5.076
    Neuregulin-1β Protects the Rat Diaphragm during Sepsis against Oxidative Stress and Inflammation by Activating the PI3K/Akt Pathway

    DOI: 10.1155/2020/1720961
    Sample: Serum,Tissue homogenate
  62. Frontiers in Immunology (2020) IF: 5.085
    Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo

    DOI: 10.3389/fimmu.2020.01611
    Sample: plasma
  63. INFLAMMOPHARMACOLOGY (2022) IF: 5.093
    Pterostilbene improves CFA-induced arthritis and peripheral neuropathy through modulation of oxidative stress, inflammatory cytokines and neurotransmitters in Wistar rats

    DOI: 10.1007/s10787-022-01069-w

    PMID: 36138303

    		 Sample: serum
  64. Frontiers in Medicine (2021) IF: 5.093
    METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis

    DOI: 10.3389/fmed.2021.607585

    PMID: 34295905

    		 Sample: synovial
  65. Cancer Nanotechnology (2022) IF: 5.095
    Histopathology, pharmacokinetics and estimation of interleukin-6 levels of Moringa oleifera leaves extract-functionalized selenium nanoparticles against rats induced hepatocellular carcinoma

    DOI: 10.1186/s12645-022-00123-0
    Sample: liver
  66. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017) IF: 5.104
    Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats

    DOI: 10.1159/000480005
    Sample: Serum
  67. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022) IF: 5.112
    Thermosensitive smart hydrogel of PEITC ameliorates the therapeutic efficacy in rheumatoid arthritis

    DOI: 10.1016/j.ejps.2022.106367
    Sample: serum
  68. CHEMICO-BIOLOGICAL INTERACTIONS (2023) IF: 5.168
    p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats

    DOI: 10.1016/j.cbi.2023.110366
    Sample: Striata
  69. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019) IF: 5.176
    Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats

    DOI: 10.1093/ijnp/pyy090
    Sample: Plasma,Tissue homogenate
  70. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022) IF: 5.19
    Mechanistic insights on the possible protective role of polyphenols extracted from Tamarix aphylla aerial parts against sodium arsenite-induced hepatotoxicity in rats

    DOI: 10.1007/s11356-022-23324-x

    PMID: 36190635

    		 Sample: serum
  71. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023) IF: 5.19
    Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats

    DOI: 10.1007/s11356-023-25917-6
    Sample: heart
  72. FASEB JOURNAL (2020) IF: 5.192
    Pre‐ischemic renal lavage protects against renal ischemia‐reperfusion injury by attenuation of local and systemic inflammatory responses

    DOI: 10.1096/fj.201902943R
    Sample: Plasma
  73. CHEMICO-BIOLOGICAL INTERACTIONS (2021) IF: 5.194
    Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals

    DOI: 10.1016/j.cbi.2021.109732

    PMID: 34737150

    		 Sample: serum
  74. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethas

    DOI: 10.1016/j.jep.2022.115939

    PMID: 36435406

    		 Sample: serum
  75. JOURNAL OF ETHNOPHARMACOLOGY (2023) IF: 5.195
    Optimal timing of free total rhubarb anthraquinones on immune regulation in rats with severe acute pancreatitis

    DOI: 10.1016/j.jep.2023.116266
    Sample: blood,Small intestine tissue
  76. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation

    DOI: 10.1016/j.jep.2022.116021
    Sample: serum
  77. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Evaluation of the in vitro and in vivo anti-inflammatory activity of Gymnosporia montana (Roth). Benth leaves

    DOI: 10.1016/j.jep.2022.115539

    PMID: 35843412

    		 Sample: RAW 264.7 cell
  78. Pharmaceuticals (2022) IF: 5.215
    Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats

    DOI: 10.3390/ph15111420
    Sample: Cardiac,Renal
  79. CNS Neuroscience & Therapeutics (2022) IF: 5.243
    Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats

    DOI: 10.1111/cns.13890

    PMID: 35695696

    		 Sample: serum
  80. NEUROPHARMACOLOGY (2022) IF: 5.251
    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation

    DOI: 10.1016/j.neuropharm.2022.108977

    PMID: 35092748

    		 Sample: hippocampus,PFC,striatum tissue
  81. BIOORGANIC CHEMISTRY (2021) IF: 5.275
    Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and mol

    DOI: 10.1016/j.bioorg.2021.105122
    Sample: serum
  82. Frontiers in Cellular and Infection Microbiology (2022) IF: 5.293
    Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy

    DOI: 10.3389/fcimb.2021.783049

    PMID: 35111693

    		 Sample: serum,hippocampal tissue
  83. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission

    DOI: 10.1111/jcmm.17062

    PMID: 34786826

    		 Sample: serum
  84. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
    Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition

    DOI: 10.1111/jcmm.16621

    PMID: 34076355

    		 Sample: lung,bronchoalveolar lavage fluid
  85. PHYTOMEDICINE (2021) IF: 5.34
    Extracts of Poria cocos improve functional dyspepsia via regulating brain-gut peptides, immunity and repairing of gastrointestinal mucosa

    DOI: 10.1016/j.phymed.2021.153875

    PMID: 34911003

    		 Sample: serum
  86. PHYTOMEDICINE (2021) IF: 5.34
    Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis

    DOI: 10.1016/j.phymed.2021.153798

    PMID: 34673348

    		 Sample: serum
  87. JOURNAL OF NEUROCHEMISTRY (2021) IF: 5.372
    Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

    DOI: 10.1111/jnc.15439

    PMID: 34050937

    		 Sample: Tissue homogenate
  88. Food & Function (2021) IF: 5.396
    Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation by activating the Nrf2 pathway

    DOI: 10.1039/D1FO01926K

    PMID: 34647944

    		 Sample: VSMC
  89. Food & Function (2022) IF: 5.396
    Asiatic acid from Cyclocarya paliurus regulates the autophagy–lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis

    DOI: 10.1039/D1FO02445K

    PMID: 35531774

    		 Sample: Urinary
  90. Chinese Medicine (2022) IF: 5.455
    Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway

    DOI: 10.1186/s13020-021-00562-8

    PMID: 35123524

    		 Sample: serum
  91. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018) IF: 5.5
    Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105

    DOI: 10.1159/000493288
    Sample: myocardial tissues
  92. Journal of the American Heart Association (2022) IF: 5.501
    Trimetazidine Alleviates Postresuscitation Myocardial Dysfunction and Improves 96‐Hour Survival in a Ventricular Fibrillation Rat Model

    DOI: 10.1161/JAHA.121.023378
    Sample: myocardial tissue
  93. Frontiers in Endocrinology (2021) IF: 5.555
    Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

    DOI: 10.3389/fendo.2021.759843

    PMID: 34777254

    		 Sample: serum
  94. Nanomedicine-Nanotechnology Biology and Medicine (2019) IF: 5.57
    Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy

    DOI: 10.1016/j.nano.2019.102017

    PMID: 31128293

    		 Sample: Plasma
  95. FOOD AND CHEMICAL TOXICOLOGY (2022) IF: 5.572
    Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway

    DOI: 10.1016/j.fct.2022.113471

    PMID: 36270409

    		 Sample: liver,kidney
  96. Metabolites (2023) IF: 5.581
    Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

    DOI: 10.3390/metabo13020167
    Sample: plasma
  97. FASEB JOURNAL (2018) IF: 5.595
    Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death

    DOI: 10.1096/fj.201800028RR
    Sample: Tissue homogenate
  98. RESPIRATORY RESEARCH (2021) IF: 5.631
    Artesunate ameliorates cigarette smoke-induced airway remodelling via PPAR-γ/TGF-β1/Smad2/3 signalling pathway

    DOI: 10.1186/s12931-021-01687-y

    PMID: 33757521

    		 Sample: BALF
  99. Molecular Therapy-Nucleic Acids (2018) IF: 5.66
    miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

    DOI: 10.1016/j.omtn.2018.01.010
    Sample: H9c2 cells
  100. Artificial Cells Nanomedicine and Biotechnology (2022) IF: 5.678
    Evaluation of tenofovir disoproxil fumarate loaded silver nanoparticle on testicular morphology in experimental type-2 diabetic rats

    DOI: 10.1080/21691401.2022.2042009

    PMID: 35343349

    		 Sample: testicular
  101. MOLECULAR NEUROBIOLOGY (2022) IF: 5.682
    Activation of Angiotensin-converting Enzyme 2 Protects Against Lipopolysaccharide-induced Glial Activation by Modulating Angiotensin-converting Enzyme 2/Angiotensin (1–7)/Mas Receptor Axis

    DOI: 10.1007/s12035-022-03061-5
    Sample: cortex,hippocampus,C6 cell
  102. REDOX REPORT (2022) IF: 5.696
    Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury

    DOI: 10.1080/13510002.2022.2129192

    PMID: 36200598

    		 Sample: ovarian
  103. GENOMICS (2021) IF: 5.736
    Up-regulated microRNA-132 reduces the cognition-damaging effect of sevoflurane on Alzheimer's disease rats by inhibiting FOXA1

    DOI: 10.1016/j.ygeno.2021.08.011

    PMID: 34400241

    		 Sample: hippocampal tissue
  104. Frontiers in Pharmacology (2021) IF: 5.811
    β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

    DOI: 10.3389/fphar.2021.689491
    Sample: Intestinal
  105. Frontiers in Pharmacology (2021) IF: 5.811
    Salvianolate Ameliorates Osteopenia and Improves Bone Quality in Prednisone-Treated Rheumatoid Arthritis Rats by Regulating RANKL/RANK/OPG Signaling

    DOI: 10.3389/fphar.2021.710169

    PMID: 34552485

    		 Sample: serum
  106. Frontiers in Pharmacology (2022) IF: 5.811
    Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1

    DOI: 10.3389/fphar.2022.859755

    PMID: 35496302

    		 Sample: H9C2 cell
  107. Frontiers in Pharmacology (2022) IF: 5.811
    Elucidation of the Mechanisms and Effective Substances of Paeoniae Radix Rubra Against Toxic Heat and Blood Stasis Syndrome With a Stage-Oriented Strategy.

    DOI: 10.3389/fphar.2022.842839
    Sample: plasma
  108. Frontiers in Pharmacology (2022) IF: 5.811
    Effects of Pereskia aculeate Miller Petroleum Ether Extract on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats and its Potential Molecular Mechanisms

    DOI: 10.3389/fphar.2022.869810
    Sample: serum
  109. Translational Stroke Research (2019) IF: 5.847
    AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

    DOI: 10.1007/s12975-019-00715-w

    PMID: 31325153

    		 Sample: Plasma
  110. Bone & Joint Research (2021) IF: 5.853
    PARP-1 inhibition attenuates the inflammatory response in the cartilage of a rat model of osteoarthritis

    DOI: 10.1302/2046-3758.107.BJR-2020-0200.R2

    PMID: 34254815

    		 Sample: serum
  111. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021) IF: 5.875
    PLGA/PCADK composite microspheres containing hyaluronic acid–chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy

    DOI: 10.1016/j.ijpharm.2021.120204
    Sample: Serum
  112. PHYTOTHERAPY RESEARCH (2021) IF: 5.882
    Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: Role of Keap-1/Nrf2/ARE, IL6/STAT-3, and NF-κB/AP-1 signaling pathways

    DOI: 10.1002/ptr.7355
    Sample: liver
  113. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021) IF: 5.924
    Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

    DOI: 10.3390/ijms221910669
    Sample: serum
  114. Frontiers in Pharmacology (2022) IF: 5.988
    Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.

    DOI: 10.3389/fphar.2022.801982
    Sample: hepatic tissue
  115. Frontiers in Pharmacology (2022) IF: 5.988
    Anti-arthritic and toxicological evaluation of ethanolic extract of Alternanthera bettzickiana in rats.

    DOI: 10.3389/fphar.2022.1002037
    Sample: serum
  116. SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2022) IF: 4.052
    Evaluation of testicular torsion management in Ogbomoso, South-Western Nigeria and surgical detorsion-augmented treatment with phytochemical fractions of Corchorus olitorius leaf in experimental rats

    DOI: 10.1016/j.sjbs.2022.103495
    Sample: testicular tissue
  117. Journal of Diabetes Research (2022) IF: 4.061
    Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats

    DOI: 10.1155/2022/1193392
    Sample: serum
  118. International Journal of Biological Sciences (2019) IF: 4.067
    Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress

    DOI: 10.7150/ijbs.38315

    PMID: 31853224

    		 Sample: Serum,Bronchoalveolar Lavage Fluid,Tissue homogena
  119. BIOLOGICAL TRACE ELEMENT RESEARCH (2023) IF: 4.081
    Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats

    DOI: 10.1007/s12011-023-03579-2
    Sample: Serum
  120. INFLAMMATION (2018) IF: 4.092
    the NF-κB Pathway in Rats

    DOI: 10.1007/s10753-018-0791-x
    Sample: Plasma
  121. INFLAMMATION (2021) IF: 4.092
    Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis

    DOI: 10.1007/s10753-021-01545-5
    Sample: serum
  122. INFLAMMATION (2021) IF: 4.092
    MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression

    DOI: 10.1007/s10753-020-01404-9

    PMID: 33492555

    		 Sample: Tissue homogenate,Cell culture supernatant
  123. INFLAMMATION (2017) IF: 4.092
    MeCP2 Regulates PTCH1 Expression Through DNA Methylation in Rheumatoid Arthritis

    DOI: 10.1007/s10753-017-0591-8
    Sample: Cell culture supernatant
  124. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.109
    hUC-MSCs exosomal miR-451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway

    DOI: 10.1002/tox.23639
    Sample: serum,NR8383 cell
  125. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway

    DOI: 10.1002/tox.23464

    PMID: 35006638

    		 Sample: bronchoalveolar lavage fluid (BALF)
  126. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    Iron-induced cellular in vitro neurotoxic responses in rat C6 cell line

    DOI: 10.1002/tox.23543

    PMID: 35446454

    		 Sample: glioma C6 cell
  127. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cell interactions

    DOI: 10.1002/tox.23324
    Sample: serum,liver
  128. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats

    DOI: 10.1002/tox.23358

    PMID: 34464015

    		 Sample: serum
  129. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide

    DOI: 10.1002/tox.23471

    PMID: 35099110

    		 Sample: serum
  130. ACS Omega (2023) IF: 4.132
    Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

    DOI: 10.1021/acsomega.2c07018
    Sample: serum
  131. ACS Omega (2022) IF: 4.132
    Comparative Biochemical Profiling of Aluminum Chloride and Sodium Azide Induced Neuroinflammation and Cardiometabolic Disturbance

    DOI: 10.1021/acsomega.2c05467

    PMID: 36385866

    		 Sample: serum
  132. ACS Omega (2022) IF: 4.132
    Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway

    DOI: 10.1021/acsomega.2c03888

    PMID: 36157749

    		 Sample: serum
  133. VASCULAR PHARMACOLOGY (2020) IF: 4.152
    Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia

    DOI: 10.1016/j.vph.2020.106827

    PMID: 33346090

    		 Sample: brain lysate supernatant
  134. Frontiers in Psychiatry (2021) IF: 4.157
    Post-weaning Social Isolated Flinders Sensitive Line Rats Display Bio-Behavioural Manifestations Resistant to Fluoxetine: A Model of Treatment-Resistant Depression

    DOI: 10.3389/fpsyt.2021.688150

    PMID: 34867504

    		 Sample: plasma
  135. TOXICOLOGY AND APPLIED PHARMACOLOGY (2021) IF: 4.219
    MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2

    DOI: 10.1016/j.taap.2021.115637

    PMID: 34217758

    		 Sample: serum
  136. Frontiers in Pharmacology (2020) IF: 4.225
    Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension

    DOI: 10.3389/fphar.2020.00687

    PMID: 32508639

    		 Sample: Tissue homogenate
  137. Frontiers in Pharmacology (2020) IF: 4.225
    Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability

    DOI: 10.3389/fphar.2020.569251
    Sample: Bronchoalveolar Lavage Fluid
  138. Journal of Clinical Medicine (2021) IF: 4.242
    Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells

    DOI: 10.3390/jcm10143143

    PMID: 34300308

    		 Sample: plasma
  139. Scientific Reports (2017) IF: 4.259
    Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF- κ B signaling pathways

    DOI: 10.1038/s41598-017-00557-2
    Sample: Tissue homogenate
  140. Scientific Reports (2017) IF: 4.259
    Effect of Qianghuo Erhuang Decoction on T Regulatory and T Helper 17 Cells in Treatment of Adjuvant-induced Arthritis in Rats

    DOI: 10.1038/s41598-017-17566-w
    Sample: Serum
  141. TOXICOLOGY LETTERS (2022) IF: 4.271
    Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein

    DOI: 10.1016/j.toxlet.2022.12.013
  142. International Journal of Nanomedicine (2017) IF: 4.3
    Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

    DOI: 10.2147/IJN.S140992
    Sample: Serum
  143. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019) IF: 4.328
    Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling

    DOI: 10.1016/j.bbadis.2019.02.020

    PMID: 30826466

    		 Sample: Serum
  144. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Ziziphus Oxyphylla hydro-methanolic extract ameliorates hypertension in L-NAME induced hypertensive rats through NO/cGMP pathway and suppression of oxidative stress related inflammatory biomarkers.

    DOI: 10.1016/j.jep.2021.114825
    Sample: Serum
  145. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway

    DOI: 10.1016/j.jep.2021.114772

    PMID: 34688801

    		 Sample: retinal tissue
  146. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways

    DOI: 10.1016/j.jep.2021.114791

    PMID: 34737112

    		 Sample: serum
  147. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier

    DOI: 10.1016/j.jep.2021.114108

    PMID: 33839199

    		 Sample: Tissue homogenate
  148. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022) IF: 4.369
    BMSC-EVs overexpressing PD-L1 ameliorate DSS-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis

    DOI: 10.1111/jgh.15987
    Sample: blood,colon
  149. Scientific Reports (2022) IF: 4.38
    Protective effect of ethanolic extract of Echinacea purpurea contained nanoparticles on meniscal/ligamentous injury induced osteoarthritis in obese male rats

    DOI: 10.1038/s41598-022-09380-w

    PMID: 35354886

    		 Sample: plasma
  150. Scientific Reports (2021) IF: 4.38
    Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

    DOI: 10.1038/s41598-021-97487-x
    Sample: serum
  151. Scientific Reports (2022) IF: 4.38
    Low-intensity low-frequency pulsed ultrasound ameliorates sciatic nerve dysfunction in a rat model of cisplatin-induced peripheral neuropathy

    DOI: 10.1038/s41598-022-11978-z

    PMID: 35581281

    		 Sample: serum
  152. Scientific Reports (2022) IF: 4.38
    Chondroitin and glucosamine sulphate reduced proinflammatory molecules in the DRG and improved axonal function of injured sciatic nerve of rats

    DOI: 10.1038/s41598-022-06554-4

    PMID: 35210446

    		 Sample: dorsal root ganglia
  153. Scientific Reports (2021) IF: 4.38
    Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-γ

    DOI: 10.1038/s41598-021-98605-5

    PMID: 34556775

    		 Sample: plasma,brain tissue,adipose tissue
  154. MOLECULAR PHARMACEUTICS (2019) IF: 4.396
    Accelerated Blood Clearance of Nanoemulsions Modified with PEG-Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights

    DOI: 10.1021/acs.molpharmaceut.9b00770

    PMID: 31860321

    		 Sample: Serum
  155. MOLECULAR IMMUNOLOGY (2017) IF: 4.407
    NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis

    DOI: 10.1016/j.molimm.2017.08.024
    Sample: Tissue homogenate,Cell lysate,Serum
  156. MOLECULES (2022) IF: 4.412
    Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways

    DOI: 10.3390/molecules27041383

    PMID: 35209172

    		 Sample: serum
  157. REDOX REPORT (2022) IF: 4.412
    Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury

    DOI: 10.1080/13510002.2022.2074128

    PMID: 35535549

    		 Sample: gastric tissue
  158. NEUROCHEMICAL RESEARCH (2022) IF: 4.414
    Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

    DOI: 10.1007/s11064-022-03800-z

    PMID: 36315371

    		 Sample: serum,white matter samples
  159. ACS Chemical Neuroscience (2021) IF: 4.418
    Synthesis and Biological Evaluation of Benzimidazole Derivatives as Potential Neuroprotective Agents in an Ethanol-Induced Rodent Model

    DOI: 10.1021/acschemneuro.0c00659

    PMID: 33430586

    		 Sample: Tissue homogenate(Brain)
  160. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4

    DOI: 10.1016/j.ejphar.2021.174351

    PMID: 34280397

    		 Sample: serum
  161. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway

    DOI: 10.1016/j.ejphar.2021.174607

    PMID: 34743981

    		 Sample: serum,sciatic nerves
  162. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 4.432
    PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis

    DOI: 10.1016/j.ejphar.2019.172558
    Sample: serum
  163. EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 4.432
    Piperazine ferulate protects against cardiac ischemia/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis

    DOI: 10.1016/j.ejphar.2022.174856

    PMID: 35219728

    		 Sample: serum
  164. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Glycyrrhizic acid ameliorates myocardial ischemia-reperfusion injury in rats through inhibiting endoplasmic reticulum stress

    DOI: 10.1016/j.ejphar.2021.174353

    PMID: 34274339

    		 Sample: serum
  165. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model

    DOI: 10.1016/j.ejphar.2021.174078

    PMID: 33839087

    		 Sample: Serum
  166. EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
    Bisindole compound 4ae ameliorated cognitive impairment in rats with vascular dementia by anti-inflammation effect via microglia cells

    DOI: 10.1016/j.ejphar.2021.174357

    PMID: 34284012

    		 Sample: BV2 cells
  167. NEUROBIOLOGY OF AGING (2018) IF: 4.454
    CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits

    DOI: 10.1016/j.neurobiolaging.2018.11.023

    PMID: 30594047

    		 Sample: Tissue homogenate,Cell culture medium
  168. INFLAMMOPHARMACOLOGY (2022) IF: 4.473
    Sarcococca saligna extract attenuates formaldehyde-induced arthritis in Wistar rats via modulation of pro-inflammatory and inflammatory biomarkers

    DOI: 10.1007/s10787-022-00929-9

    PMID: 35218463

    		 Sample: blood
  169. INFLAMMOPHARMACOLOGY (2021) IF: 4.473
    Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat

    DOI: 10.1007/s10787-021-00832-9

    PMID: 34106384

    		 Sample: serum
  170. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018) IF: 4.491
    Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis

    DOI: 10.1016/j.ejpb.2018.06.020
    Sample: Plasma
  171. JOURNAL OF CELLULAR PHYSIOLOGY (2019) IF: 4.522
    Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5

    DOI: 10.1002/jcp.28126

    PMID: 30644097

    		 Sample: Serum
  172. JOURNAL OF CELLULAR PHYSIOLOGY (2019) IF: 4.522
    C1q/TNF‐related protein‐9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction

    DOI: 10.1002/jcp.28513
    Sample: Tissue homogenate
  173. PSYCHOPHARMACOLOGY (2021) IF: 4.53
    Selenium abates manganese–induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats

    DOI: 10.1007/s00213-021-06010-7
    Sample: striatum,hippocampus
  174. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats

    DOI: 10.1016/j.biopha.2020.110400

    PMID: 32570115

    		 Sample: Serum
  175. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota

    DOI: 10.1016/j.biopha.2020.109829

    PMID: 31958765

    		 Sample: Tissue homogenate
  176. SAUDI PHARMACEUTICAL JOURNAL (2023) IF: 4.562
    6-gingerol ameliorates weight gain and insulin resistance in metabolic syndrome rats by regulating adipocytokines

    DOI: 10.1016/j.jsps.2023.01.003
    Sample: serum,liver,adipose tissue
  177. Frontiers in Physiology (2021) IF: 4.566
    Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats

    DOI: 10.3389/fphys.2021.639454
    Sample: serum
  178. REPRODUCTIVE BIOMEDICINE ONLINE (2023) IF: 4.567
    Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and anti-angiogenic effects in an experimental rat model

    DOI: 10.1016/j.rbmo.2023.01.018
    Sample: Serum,intraperitoneal fluid
  179. TOXICOLOGY (2022) IF: 4.571
    Zinc and selenium mitigated heavy metals mixture (Pb, Al, Hg and Mn) mediated hepatic-nephropathy via modulation of oxido-inflammatory status and NF‑kB signaling in female albino rats

    DOI: 10.1016/j.tox.2022.153350

    PMID: 36220500

    		 Sample: liver,kidney
  180. Oxidative Medicine and Cellular Longevity (2017) IF: 4.593
    Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils

    DOI: 10.1155/2017/3869561
    Sample: Cell culture supernatant
  181. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020) IF: 4.604
    Study of double-targeting nanoparticles loaded with MCL-1 siRNA and dexamethasone for adjuvant-induced arthritis therapy

    DOI: 10.1016/j.ejpb.2020.07.009

    PMID: 32681961

    		 Sample: Serum
  182. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016) IF: 4.652
    Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway

    DOI: 10.1159/000445586
    Sample: Tissue homogenate
  183. INFLAMMATION (2022) IF: 4.657
    Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury

    DOI: 10.1007/s10753-022-01762-6
    Sample: lung tissue
  184. INFLAMMATION (2022) IF: 4.657
    Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study

    DOI: 10.1007/s10753-022-01763-5
    Sample: knee articular tissue
  185. Plants-Basel (2023) IF: 4.658
    The Effect of Extraction Methods on Phytochemicals and Biological Activities of Green Coffee Beans Extracts

    DOI: 10.3390/plants12040712
    Sample: plantar tissue
  186. Plants-Basel (2022) IF: 4.658
    Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts

    DOI: 10.3390/plants12010096
    Sample: plantar tissue
  187. Frontiers in Neuroscience (2021) IF: 4.677
    Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

    DOI: 10.3389/fnins.2020.589650

    PMID: 33584172

    		 Sample: Plasma
  188. MEDIATORS OF INFLAMMATION (2020) IF: 4.711
    Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis

    DOI: 10.1155/2020/1320278

    PMID: 33061821

    		 Sample: Serum
  189. Frontiers in Physiology (2023) IF: 4.755
    Effects of different simulated submarine escape depths by free ascent in animal models

    DOI: 10.3389/fphys.2023.1107782
    Sample: Serum
  190. Biomedicines (2022) IF: 4.757
    Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats

    DOI: 10.3390/biomedicines10071620

    PMID: 35884925

    		 Sample: lymphocytes
  191. Biomedicines (2022) IF: 4.757
    Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study

    DOI: 10.3390/biomedicines10071613

    PMID: 35884918

    		 Sample: Serum
  192. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019) IF: 4.784
    Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing

    DOI: 10.1016/j.ijbiomac.2019.09.219

    PMID: 31647938

    		 Sample: Serum,Tissue homogenate
  193. Oxidative Medicine and Cellular Longevity (2019) IF: 4.868
    Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo

    DOI: 10.1155/2019/7285434
    Sample: serum,LV(left ventricular) myocardium,H9c2 cells
  194. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016) IF: 4.874
    Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: The regulation of autophagy and ROS production

    DOI: 10.1016/j.yjmcc.2016.10.017
    Sample: Serum
  195. MOLECULES (2022) IF: 4.927
    Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury

    DOI: 10.3390/molecules27165073

    PMID: 36014309

    		 Sample: intestinal,hepatic
  196. MOLECULES (2022) IF: 4.927
    Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

    DOI: 10.3390/molecules27227951
    Sample: brain
  197. MOLECULES (2022) IF: 4.927
    7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

    DOI: 10.3390/molecules27175371

    PMID: 36080137

    		 Sample: serum
  198. Metabolites (2022) IF: 4.932
    Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model

    DOI: 10.3390/metabo12060479

    PMID: 35736412

    		 Sample: serum
  199. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 4.932
    MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis

    DOI: 10.1016/j.intimp.2019.105900
    Sample: FLSs cells
  200. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 4.932
    Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway

    DOI: 10.1016/j.intimp.2019.105697
    Sample: brain
  201. Oxidative Medicine and Cellular Longevity (2018) IF: 4.936
    Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways

    DOI: 10.1155/2018/9647809
    Sample: Cells
  202. Journal of Inflammation Research (2020) IF: 4.953
    Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro

    DOI: 10.2147/JIR.S273858

    PMID: 32982368

    		 Sample: Cell culture supernatant,Tissue homogenate
  203. FASEB JOURNAL (2020) IF: 4.966
    TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling

    DOI: 10.1096/fj.201902496RR
    Sample: retinas
  204. Scientific Reports (2023) IF: 4.996
    Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats

    DOI: 10.1038/s41598-023-28893-6
    Sample: brain
  205. PLANTA MEDICA (2022) IF: 3.007
    Curative effect and mechanisms of Radix Arnebiae oil on burn wound healing in rats

    DOI: 10.1055/a-1997-5566
    Sample: burn wound tissue
  206. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    Ulinastatin reduces myocardial injury induced by doxorubicin in SD rats.

    DOI: 10.26355/eurrev_202010_23437
    Sample: Serum
  207. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    The effect of myocardial infarction-associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats.

    DOI: 10.26355/eurrev_202006_21528
    Sample: Serum
  208. NEUROSCIENCE LETTERS (2020) IF: 3.046
    The novel estrogen receptor GPER1 decreases epilepsy severity and susceptivity in the hippocampus after status epilepticus

    DOI: 10.1016/j.neulet.2020.134978
    Sample: Hippocampus
  209. SHOCK (2016) IF: 3.048
    EFFECT OF INTRAPERITONEAL RESUSCITATION WITH DIFFERENT CONCENTRATIONS OF SODIUM PYRUVATE ON INTESTINAL ISCHEMIA REPERFUSION INJURY IN HEMORRHAGIC SHOCK RAT

    DOI: 10.1097/SHK.0000000000000515
    Sample: intestinal tissue
  210. JOURNAL OF CHEMICAL NEUROANATOMY (2021) IF: 3.052
    DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway

    DOI: 10.1016/j.jchemneu.2021.102032

    PMID: 34562585

    		 Sample: Hippocampal tissue
  211. JOURNAL OF ETHNOPHARMACOLOGY (2016) IF: 3.055
    Venenum Bufonis induces rat neuroinflammation by activiating NF-κB pathway and attenuation of BDNF

    DOI: 10.1016/j.jep.2016.03.049
    Sample: Tissue homogenate
  212. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020) IF: 3.056
    Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway

    DOI: 10.1007/s11356-020-10042-5

    PMID: 32671702

    		 Sample: Serum
  213. MOLECULES (2019) IF: 3.06
    Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors

    DOI: 10.3390/molecules24020340

    PMID: 30669379

    		 Sample: Plasma,Tissue homogenate
  214. PeerJ (2022) IF: 3.061
    Effects of combination of obesity, diabetes, and hypoxia on inflammatory regulating genes and cytokines in rat pancreatic tissues and serum

    DOI: 10.7717/peerj.13990

    PMID: 36213511

    		 Sample: serum
  215. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019) IF: 3.091
    Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

    DOI: 10.1111/aji.13096
    Sample: Serum
  216. PHYTOTHERAPY RESEARCH (2017) IF: 3.092
    Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen‐Induced Arthritis

    DOI: 10.1002/ptr.5775
    Sample: Cell culture supernatant
  217. RSC Advances (2017) IF: 3.108
    Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model

    DOI: 10.1039/C7RA11748E
    Sample: plasma
  218. EXPERIMENTAL BIOLOGY AND MEDICINE (2020) IF: 3.139
    H2S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty:

    DOI: 10.1177/1535370220961038
    Sample: Plasma
  219. REPRODUCTIVE TOXICOLOGY (2022) IF: 3.143
    Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries

    DOI: 10.1016/j.reprotox.2022.03.006

    PMID: 35307492

    		 Sample: serum
  220. IMMUNOBIOLOGY (2023) IF: 3.152
    STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation

    DOI: 10.1016/j.imbio.2023.152345
    Sample: lung tissues,Bone marrow-derived macrophage (BMDMs
  221. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 3.17
    Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease

    DOI: 10.1016/j.ejphar.2019.172699
    Sample: serum
  222. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 3.17
    Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis

    DOI: 10.1016/j.ejphar.2019.172786

    PMID: 31712060

    		 Sample: Serum
  223. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2017) IF: 3.176
    Small Molecule Inhibiting Nuclear Factor‐kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat

    DOI: 10.1111/bcpt.12718
    Sample: Tissue homogenate
  224. NEUROSCIENCE LETTERS (2022) IF: 3.197
    Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation

    DOI: 10.1016/j.neulet.2022.136787

    PMID: 35820551

    		 Sample: serum
  225. Drug Design Development and Therapy (2020) IF: 3.216
    KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats

    DOI: 10.2147/DDDT.S227651
    Sample: intestinal tissue
  226. PLoS One (2015) IF: 3.234
    Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke

    DOI: 10.1371/journal.pone.0129881
    Sample: Tissue homogenate
  227. MOLECULAR IMMUNOLOGY (2017) IF: 3.236
    The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

    DOI: 10.1016/j.molimm.2017.12.008
    Sample: Bronchoalveolar Lavage Fluid,Serum,Tissue homogena
  228. PLoS One (2022) IF: 3.24
    The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis

    DOI: 10.1371/journal.pone.0264558

    PMID: 35213638

    		 Sample: serum
  229. PLoS One (2021) IF: 3.24
    Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model

    DOI: 10.1371/journal.pone.0260546

    PMID: 34879109

    		 Sample: Plasma,liver tissue,adipose tissue
  230. PHYSIOLOGY & BEHAVIOR (2021) IF: 3.244
    Thromboxane A2 synthase inhibition ameliorates endothelial dysfunction, memory deficits, oxidative stress and neuroinflammation in rat model of streptozotocin diabetes induced dementia

    DOI: 10.1016/j.physbeh.2021.113592

    PMID: 34534530

    		 Sample: brain
  231. Biomed Research International (2022) IF: 3.246
    Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

    DOI: 10.1155/2022/5894416
    Sample: heart tissue
  232. Life-Basel (2023) IF: 3.251
    Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation

    DOI: 10.3390/life13020388
    Sample: gastric tissue
  233. JOURNAL OF GENE MEDICINE (2020) IF: 3.258
    Celastrol mitigates high glucose‐induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR‐345‐5p/growth arrest‐specific 6

    DOI: 10.1002/jgm.3201
    Sample: H9c2 cell
  234. BMC Endocrine Disorders (2022) IF: 3.263
    Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model

    DOI: 10.1186/s12902-022-01143-y

    PMID: 36071485

    		 Sample: adipose tissue
  235. EUROPEAN JOURNAL OF PHARMACOLOGY (2020) IF: 3.263
    Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation

    DOI: 10.1016/j.ejphar.2020.173734

    PMID: 33220272

    		 Sample: Tissue homogenate(Hippocampal tissues)
  236. American Journal of Translational Research (2019) IF: 3.266
    Protective effects of Ulinastatin on oxidative stress and inflammation of rat-derived cardiomyocytes H9c2

    PMID: 31814912

    		 Sample: H9c2 cells
  237. MOLECULES (2020) IF: 3.267
    Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats

    DOI: 10.3390/molecules25051177
    Sample: serum
  238. Bioengineered (2021) IF: 3.269
    DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis

    DOI: 10.1080/21655979.2021.2005308

    PMID: 34783292

    		 Sample: synovial fluid
  239. Bioengineered (2021) IF: 3.269
    Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes

    DOI: 10.1080/21655979.2021.1999554

    PMID: 34719315

    		 Sample: serum
  240. IMMUNOLOGY LETTERS (2020) IF: 3.276
    Protective effect of Ganoderic acid A on adjuvant-induced arthritis

    DOI: 10.1016/j.imlet.2020.06.010

    PMID: 32565114

    		 Sample: Serum
  241. BMC NEUROSCIENCE (2021) IF: 3.288
    Metformin attenuates sepsis-induced neuronal injury and cognitive impairment

    DOI: 10.1186/s12868-021-00683-8

    PMID: 34911449

    		 Sample: hippocampus tissue
  242. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020) IF: 3.292
    Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress

    DOI: 10.1016/j.etap.2020.103456

    PMID: 32673753

    		 Sample: Serum,Tissue homogenate
  243. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020) IF: 3.292
    Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance

    DOI: 10.1016/j.etap.2020.103506

    PMID: 33002592

    		 Sample: Serum
  244. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020) IF: 3.292
    Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways

    DOI: 10.1016/j.etap.2020.103387

    PMID: 32339907

    		 Sample: Serum
  245. INFLAMMOPHARMACOLOGY (2018) IF: 3.304
    SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

    DOI: 10.1007/s10787-018-0522-9

    PMID: 30094758

    		 Sample: Tissue homogenate
  246. INFLAMMOPHARMACOLOGY (2018) IF: 3.304
    ) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study

    DOI: 10.1007/s10787-017-0432-2
    Sample: serum
  247. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2019) IF: 3.319
    Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats

    DOI: 10.2147/DMSO.S183811
    Sample: Tissue homogenate,Plasma
  248. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023) IF: 3.322
    Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis

    DOI: 10.1016/j.bbrc.2023.01.046
    Sample: Serum,amygdala
  249. BEHAVIOURAL BRAIN RESEARCH (2021) IF: 3.332
    Modulation of nociception and pain-evoked neurobehavioral responses by levetiracetam in a craniotomy pain model

    DOI: 10.1016/j.bbr.2021.113728

    PMID: 34952028

    		 Sample: serum
  250. Separations (2023) IF: 3.344
    Wound Healing Activity of the Flavonoid-Enriched Fraction of Selaginella bryopteris Linn. against Streptozocin-Induced Diabetes in Rats

    DOI: 10.3390/separations10030166
    Sample: skin
  251. TOXICOLOGY AND APPLIED PHARMACOLOGY (2020) IF: 3.347
    Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS

    DOI: 10.1016/j.taap.2020.115381

    PMID: 33359182

    		 Sample: Plasma
  252. TOXICOLOGY AND APPLIED PHARMACOLOGY (2020) IF: 3.347
    Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats

    DOI: 10.1016/j.taap.2020.115101
    Sample: Serum
  253. International Journal of Chronic Obstructive Pulmonary Disease (2022) IF: 3.355
    The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

    DOI: 10.2147/COPD.S359428

    PMID: 35673595

    		 Sample: lung tissue
  254. DRUG AND CHEMICAL TOXICOLOGY (2021) IF: 3.356
    Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability

    DOI: 10.1080/01480545.2021.1997541

    PMID: 34747284

    		 Sample: intestinal
  255. INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
    The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats

    DOI: 10.1016/j.intimp.2019.105978

    PMID: 31767546

    		 Sample: Tissue homogenate
  256. RSC Advances (2021) IF: 3.361
    Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis

    DOI: 10.1039/D0RA08689D
    Sample: Serum
  257. BIOCHIMIE (2019) IF: 3.362
    TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid

    DOI: 10.1016/j.biochi.2019.04.013
    Sample: serum,adipocytes
  258. Frontiers in Physiology (2020) IF: 3.367
    Effect of Clostridium butyricum and Butyrate on Intestinal Barrier Functions: Study of a Rat Model of Severe Acute Pancreatitis With Intra-Abdominal Hypertension

    DOI: 10.3389/fphys.2020.561061

    PMID: 33192557

    		 Sample: Plasma
  259. BRAIN RESEARCH BULLETIN (2020) IF: 3.37
    Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response

    DOI: 10.1016/j.brainresbull.2020.10.006

    PMID: 33053435

    		 Sample: Tissue homogenate
  260. EXPERIMENTAL CELL RESEARCH (2020) IF: 3.383
    iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction

    DOI: 10.1016/j.yexcr.2020.112086
    Sample: Serum,Cell sample
  261. Biomed Research International (2021) IF: 3.411
    Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor

    DOI: 10.1155/2021/6631415

    PMID: 33628797

    		 Sample: Tissue homogenate( liver)
  262. Biomed Research International (2021) IF: 3.411
    Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model

    DOI: 10.1155/2021/5574207
    Sample: brain
  263. JOURNAL OF ETHNOPHARMACOLOGY (2019) IF: 3.414
    Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes

    DOI: 10.1016/j.jep.2019.112124
    Sample: serum
  264. DISEASE MARKERS (2021) IF: 3.434
    The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats

    DOI: 10.1155/2021/2821673

    PMID: 34745386

    		 Sample: serum
  265. LIFE SCIENCES (2019) IF: 3.448
    Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes

    DOI: 10.1016/j.lfs.2019.117045

    PMID: 31730866

    		 Sample: Serum
  266. JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
    Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study

    DOI: 10.1002/jcb.28976

    PMID: 31099131

    		 Sample: Tissue homogenate
  267. SHOCK (2021) IF: 3.454
    Comparison of the Protective Effect of Different Mild Therapeutic Hypothermia Temperatures on Intestinal Injury After Cardiopulmonary Resuscitation in Rats

    DOI: 10.1097/SHK.0000000000001745

    PMID: 33555844

    		 Sample: plasma,intestinal tissue
  268. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity

    DOI: 10.1016/j.biopha.2018.07.081
    Sample: Serum
  269. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats

    DOI: 10.1016/j.biopha.2018.01.085
    Sample: plasma
  270. EXPERIMENTAL EYE RESEARCH (2022) IF: 3.467
    A modified high-yield method for primary culture of rat retinal microglial cells

    DOI: 10.1016/j.exer.2021.108919

    PMID: 34979098

    		 Sample: microglial cell
  271. JOURNAL OF NEUROIMMUNOLOGY (2022) IF: 3.478
    Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats

    DOI: 10.1016/j.jneuroim.2022.577894

    PMID: 35642994

    		 Sample: Brain tissue
  272. PHARMACEUTICAL BIOLOGY (2021) IF: 3.503
    Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet

    DOI: 10.1080/13880209.2021.1970199

    PMID: 34493166

    		 Sample: plasma
  273. PHARMACEUTICAL BIOLOGY (2021) IF: 3.503
    Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis

    DOI: 10.1080/13880209.2021.1876100
    Sample: serum
  274. PHARMACEUTICAL BIOLOGY (2022) IF: 3.503
    Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway

    DOI: 10.1080/13880209.2022.2070221

    PMID: 35635784

    		 Sample: serum
  275. European Review for Medical and Pharmacological Sciences (2018) IF: 3.507
    Renal ischemia-reperfusion injury attenuated by splenic ischemic preconditioning.

    DOI: 10.26355/eurrev_201804_14747
    Sample: serum
  276. ORAL DISEASES (2021) IF: 3.511
    Pilocarpine improves submandibular gland dysfunction in irradiated rats by downregulating the tight junction protein claudin-4

    DOI: 10.1111/odi.13870
    Sample: glands
  277. ACS Omega (2022) IF: 3.512
    Sarcococca saligna Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund’s Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers

    DOI: 10.1021/acsomega.2c00619
    Sample: serum
  278. ACS Omega (2021) IF: 3.512
    Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS)

    DOI: 10.1021/acsomega.0c05281

    PMID: 33521454

    		 Sample: Cell culture supernatant
  279. Oxidative Medicine and Cellular Longevity (2015) IF: 3.516
    Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator

    DOI: 10.1155/2015/965961
    Sample: Serum
  280. MEDIATORS OF INFLAMMATION (2019) IF: 3.545
    High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis

    DOI: 10.1155/2019/2512687
    Sample: serum
  281. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.568
    Exposure of aluminium to C6 glioma cells modulates molecular and functional neurotoxic markers

    DOI: 10.1002/jbt.23210

    PMID: 36056780

    		 Sample: C6 cell
  282. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.568
    Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

    DOI: 10.1002/jbt.23240
    Sample: blood
  283. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022) IF: 3.575
    Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ

    DOI: 10.1016/j.bbrc.2022.03.015

    PMID: 35316762

    		 Sample: sera
  284. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021) IF: 3.575
    Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis

    DOI: 10.1016/j.bbrc.2021.07.026

    PMID: 34271433

    		 Sample: serum
  285. METABOLIC BRAIN DISEASE (2021) IF: 3.584
    Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin

    DOI: 10.1007/s11011-020-00657-5

    PMID: 33411217

    		 Sample: hippocampal tissues
  286. NEUROSCIENCE (2018) IF: 3.59
    Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest

    DOI: 10.1016/j.neuroscience.2018.09.041

    PMID: 30300703

    		 Sample: Serum
  287. PHYTOMEDICINE (2018) IF: 3.61
    Epigallocatechin gallate attenuates mitochondrial DNA-induced inflammatory damage in the development of ventilator-induced lung injury

    DOI: 10.1016/j.phymed.2018.05.017
    Sample: Tissue homogenate
  288. ENDOCRINE (2022) IF: 3.633
    Acetate-mediated-obestatin modulation attenuates adipose-hepatic dysmetabolism in high fat diet-induced obese rat model

    DOI: 10.1007/s12020-022-03023-w

    PMID: 35229234

    		 Sample: plasma,adipose,hepatic
  289. LIFE SCIENCES (2020) IF: 3.647
    Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats

    DOI: 10.1016/j.lfs.2020.118750

    PMID: 33188836

    		 Sample: Serum
  290. LIFE SCIENCES (2020) IF: 3.647
    IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway

    DOI: 10.1016/j.lfs.2020.118752

    PMID: 33188834

    		 Sample: Cell culture supernatant
  291. LIFE SCIENCES (2020) IF: 3.647
    Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway.

    DOI: 10.1016/j.lfs.2020.118016
    Sample: Serum
  292. LIFE SCIENCES (2020) IF: 3.647
    Attenuation of chronic arsenic neurotoxicity via melatonin in male offspring of maternal rats exposed to arsenic during conception: Involvement of oxidative DNA damage and inflammatory signaling cascades

    DOI: 10.1016/j.lfs.2020.118876

    PMID: 33310035

    		 Sample: Tissue homogenate
  293. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.652
    The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway

    DOI: 10.1002/jbt.23080
    Sample: heart tissue
  294. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.652
    Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis

    DOI: 10.1002/jbt.23147
    Sample: gastric tissue
  295. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022) IF: 3.652
    Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF-κB p65, and cleaved caspase-3 expressions

    DOI: 10.1002/jbt.23046

    PMID: 35315168

    		 Sample: Renal
  296. JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 3.654
    Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers

    DOI: 10.1111/jfbc.14389

    PMID: 36121315

    		 Sample: serum
  297. IMMUNOLOGICAL INVESTIGATIONS (2020) IF: 3.657
    Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase‑1/IL‑1β Signaling Pathway Inhibition

    DOI: 10.1080/08820139.2020.1791178
    Sample: Cell culture supernatant
  298. BMC Complementary and Alternative Medicine (2021) IF: 3.659
    Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

    DOI: 10.1186/s12906-021-03447-3
    Sample: plasma
  299. CELL CYCLE (2020) IF: 3.699
    Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133

    DOI: 10.1080/15384101.2020.1814025

    PMID: 32897801

    		 Sample: Cell culture supernatant
  300. Diagnostics (2022) IF: 3.706
    Combination Antiretroviral Therapy (cART) in Diabetes Exacerbates Diabetogenic Effects on Hippocampal Microstructure, Neurogenesis and Cytokine Perturbation in Male Sprague Dawley Rats

    DOI: 10.3390/diagnostics12040905

    PMID: 35453953

    		 Sample: brain
  301. NEUROSCIENCE (2023) IF: 3.708
    Essential Trace Elements Prevent the Impairment in the Retention Memory, Cerebral Cortex, and Cerebellum Damage in Male Rats Exposed to Quaternary Metal Mixture by Up-regulation, of Heme Oxygynase-1 and Down-regulation of Nuclear Factor Erythroid 2-relate

    DOI: 10.1016/j.neuroscience.2023.01.002

    PMID: 36646412

    		 Sample: cerebral cortex,cerebellum
  302. BIOLOGICAL TRACE ELEMENT RESEARCH (2022) IF: 3.738
    Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals

    DOI: 10.1007/s12011-022-03286-4
    Sample: kidney
  303. BIOMEDICINE & PHARMACOTHERAPY (2019) IF: 3.743
    HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury

    DOI: 10.1016/j.biopha.2019.109005
    Sample: serum,Human Umbilical Vein Endothelial Cells (HUVE
  304. BIOMEDICINE & PHARMACOTHERAPY (2019) IF: 3.743
    Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

    DOI: 10.1016/j.biopha.2019.109102
    Sample: brain
  305. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018) IF: 3.755
    Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model

    DOI: 10.1016/j.jtemb.2018.03.017
    Sample: plasma
  306. MEDIATORS OF INFLAMMATION (2020) IF: 3.758
    Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway

    DOI: 10.1155/2020/8641026
    Sample: Soil,Water,Oil,Plant Tissue,Plant Fluid,Antibody,F
  307. Heliyon (2022) IF: 3.776
    Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats

    DOI: 10.1016/j.heliyon.2022.e10887
    Sample: blood,caecum
  308. CERAMICS INTERNATIONAL (2020) IF: 3.83
    Synthesis and characterization of barium-doped bioactive glass with potential anti-inflammatory activity

    DOI: 10.1016/j.ceramint.2020.11.068
    Sample: Cell culture supernatant
  309. Frontiers in Pharmacology (2018) IF: 3.831
    PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro

    DOI: 10.3389/fphar.2018.01432

    PMID: 30564127

    		 Sample: Serum,Cell culture supernatant
  310. Frontiers in Pharmacology (2019) IF: 3.845
    Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes

    DOI: 10.3389/fphar.2019.00288
    Sample: hippocampus tissues
  311. PEPTIDES (2023) IF: 3.867
    Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier

    DOI: 10.1016/j.peptides.2023.170945
    Sample: brain
  312. REPRODUCTION (2021) IF: 3.906
    Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway

    DOI: 10.1530/REP-20-0643

    PMID: 33989172

    		 Sample: Ovary
  313. Annals of Translational Medicine (2022) IF: 3.932
    MMP2/9 downregulation is responsible for hepatic function recovery in cirrhotic rats following associating liver partition and portal vein ligation for staged hepatectomy

    DOI: 10.21037/atm-22-1312
    Sample: serum
  314. Annals of Translational Medicine (2021) IF: 3.932
    Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B

    DOI: 10.21037/atm-21-934

    PMID: 33850900

    		 Sample: Serum
  315. American Journal of Translational Research (2022) IF: 3.94
    Senomorphic agent pterostilbene ameliorates osteoarthritis through the PI3K/AKT/NF-κB axis: an in vitro and in vivo study.

    PMID: 36105068

    		 Sample: knee intra-articular lavage fluid
  316. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats

    DOI: 10.1016/j.intimp.2020.106615

    PMID: 32447219

    		 Sample: Plasma
  317. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats

    DOI: 10.1016/j.intimp.2020.106582

    PMID: 32438076

    		 Sample: Plasma
  318. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

    DOI: 10.1016/j.intimp.2020.106771

    PMID: 32683302

    		 Sample: Serum
  319. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway

    DOI: 10.1016/j.intimp.2020.106653
    Sample: H9c2 cell
  320. THROMBOSIS RESEARCH (2021) IF: 3.944
    Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis

    DOI: 10.1016/j.thromres.2021.09.014

    PMID: 34583153

    		 Sample: blood
  321. Obesity (2019) IF: 3.969
    Liraglutide Lowers Body Weight Set Point in DIO Rats and its Relationship with Hypothalamic Microglia Activation

    DOI: 10.1002/oby.22666

    PMID: 31773909

    		 Sample: Cell culture supernatant
  322. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018) IF: 3.974
    Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide

    DOI: 10.1016/j.ecoenv.2018.10.064

    PMID: 30384172

    		 Sample: Tissue homogenate
  323. NEUROTOXICITY RESEARCH (2022) IF: 3.978
    Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

    DOI: 10.1007/s12640-022-00600-9
    Sample: primary astrocyte cell
  324. JOURNAL OF SURGICAL RESEARCH (2013) IF: 2.018
    Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo

    DOI: 10.1016/j.jss.2013.02.051
    Sample: Tissue homogenate
  325. BMC Complementary and Alternative Medicine (2015) IF: 2.02
    Edible Bird’s Nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes

    DOI: 10.1186/s12906-015-0843-9
    Sample: Serum
  326. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019) IF: 2.041
    The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer

    DOI: 10.1139/cjpp-2019-0329
    Sample: serum
  327. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021) IF: 2.043
    miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte

    DOI: 10.1093/bbb/zbaa009

    PMID: 33604630

    		 Sample: Cell culture supernatant(H9c2 cells)
  328. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020) IF: 2.05
    Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats

    DOI: 10.1007/s00210-020-01870-w

    PMID: 32383030

    		 Sample: Serum
  329. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology (2021) IF: 2.064
    Electroacupuncture restores intestinal mucosal barrier through TLR4/NF-κB p65 pathway in functional dyspepsia-like rats

    DOI: 10.1002/ar.24800

    PMID: 34713984

    		 Sample: Blood
  330. Brain and Behavior (2020) IF: 2.091
    Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood

    DOI: 10.1002/brb3.1801
    Sample: hippocampal tissue
  331. Molecular Medicine Reports (2020) IF: 2.1
    Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

    DOI: 10.3892/mmr.2020.11312

    PMID: 32705206

    		 Sample: Serum
  332. MOLECULAR BIOLOGY REPORTS (2019) IF: 2.107
    A. Chev root extracts against induced testicular inflammation and impaired spermatogenesis in adult rats

    DOI: 10.1007/s11033-019-05033-w
    Sample: Serum,Tissue homogenate
  333. Iranian Journal of Basic Medical Sciences (2020) IF: 2.146
    Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain

    DOI: 10.22038/ijbms.2020.45193.10527

    PMID: 33149866

    		 Sample: Tissue homogenate
  334. NEUROSCIENCE LETTERS (2018) IF: 2.159
    Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

    DOI: 10.1016/j.neulet.2018.06.023
    Sample: Tissue homogenate
  335. BMC Cardiovascular Disorders (2022) IF: 2.174
    Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats

    DOI: 10.1186/s12872-022-02977-z
    Sample: serum
  336. Biomed Research International (2019) IF: 2.197
    MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway

    DOI: 10.1155/2019/2821731
    Sample: serum
  337. Open Medicine (2022) IF: 2.199
    Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization

    DOI: 10.1515/med-2022-0480
    Sample: HAPI cell
  338. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018) IF: 2.21
    Histopathological and biochemical changes in the development of nonalcoholic fatty liver disease induced by high-sucrose diet at different times

    DOI: 10.1139/cjpp-2018-0353

    PMID: 30388378

    		 Sample: Serum
  339. ARCHIVES OF MEDICAL RESEARCH (2021) IF: 2.235
    Effect of Pramipexole on Inflammatory Response in Central Nervous System of Parkinson's Disease Rat Model

    DOI: 10.1016/j.arcmed.2021.06.007

    PMID: 34218945

    		 Sample: brain
  340. Computational and Mathematical Methods in Medicine (2021) IF: 2.238
    Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway

    DOI: 10.1155/2021/6415275

    PMID: 34422094

    		 Sample: H9c2 cell
  341. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017) IF: 2.341
    SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22

    DOI: 10.3892/ijmm.2016.2806
    Sample: Tissue homogenate
  342. PeerJ (2019) IF: 2.353
    Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats

    DOI: 10.7717/peerj.7117
    Sample: serum
  343. AUTOIMMUNITY (2019) IF: 2.403
    The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model

    DOI: 10.1080/08916934.2019.1575820

    PMID: 30776930

    		 Sample: Plasma
  344. Canadian Respiratory Journal (2022) IF: 2.409
    Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats

    DOI: 10.1155/2022/8509396

    PMID: 35465190

    		 Sample: BALF
  345. METABOLIC BRAIN DISEASE (2019) IF: 2.411
    attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells

    DOI: 10.1007/s11011-019-00440-1
    Sample: PC12 cells
  346. Experimental and Therapeutic Medicine (2019) IF: 2.447
    H2S attenuates sepsis‑induced cardiac dysfunction via a PI3K/Akt‑dependent mechanism

    DOI: 10.3892/etm.2019.7440
    Sample: serum
  347. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Graphene oxide induces dose‑dependent lung injury in rats by regulating autophagy

    DOI: 10.3892/etm.2021.9893
    Sample: Tissue homogenate
  348. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Gadolinium chloride pre‑treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis

    DOI: 10.3892/etm.2021.10577
    Sample: serum,intestinal tissue
  349. Experimental and Therapeutic Medicine (2018) IF: 2.447
    Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

    DOI: 10.3892/etm.2018.6430
    Sample: Serum,Tissue homogenate
  350. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017) IF: 2.466
    Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway

    DOI: 10.1016/j.bbrc.2017.11.072
    Sample: Tissue homogenate
  351. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017) IF: 2.466
    Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signaling

    DOI: 10.1016/j.bbrc.2017.10.165
    Sample: Serum
  352. TISSUE & CELL (2021) IF: 2.466
    Contraceptive potential of Andrographis paniculata is via androgen suppression and not induction of oxidative stress in male Wistar rats

    DOI: 10.1016/j.tice.2021.101632

    PMID: 34479074

    		 Sample: testicular
  353. Journal of Ovarian Research (2019) IF: 2.469
    Abnormal expression of HSP70 may contribute to PCOS pathology

    DOI: 10.1186/s13048-019-0548-7
    Sample: serum
  354. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2022) IF: 2.471
    Healing Potential of Propolis Extract–Passiflora edulis Seed Oil Emulgel Against Excisional Wound: Biochemical, Histopathological, and Cytokines Level Evidence

    DOI: 10.1089/adt.2022.075
    Sample: Skin samples
  355. Immunity Inflammation and Disease (2022) IF: 2.493
    Dexamethasone and potassium canrenoate alleviate hyperalgesia by competitively regulating IL-6/JAK2/STAT3 signaling pathway during inflammatory pain in vivo and in vitro

    DOI: 10.1002/iid3.721

    PMID: 36301041

    		 Sample: spinal cord
  356. Cardiovascular Engineering and Technology (2021) IF: 2.495
    The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways

    DOI: 10.1007/s13239-021-00589-w

    PMID: 34859377

    		 Sample: H9c2 cell
  357. GENE (2018) IF: 2.498
    MicroRNA-24 regulates vascular remodeling via inhibiting PDGF-BB pathway in diabetic rat model

    DOI: 10.1016/j.gene.2018.03.056
    Sample: Tissue homogenate
  358. BIOSCIENCE REPORTS (2019) IF: 2.535
    Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors

    DOI: 10.1042/BSR20190749
    Sample: brain,neural stem cells
  359. BIOSCIENCE REPORTS (2019) IF: 2.535
    Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo

    DOI: 10.1042/BSR20180787

    PMID: 30610157

    		 Sample: Tissue homogenate
  360. Cardiovascular Therapeutics (2020) IF: 2.538
    Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers

    DOI: 10.1155/2020/1936406

    PMID: 32117470

    		 Sample: Plasma,Tissue homogenate
  361. TISSUE & CELL (2022) IF: 2.586
    Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats

    DOI: 10.1016/j.tice.2022.101953

    PMID: 36228366

    		 Sample: Lung tissue
  362. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2017) IF: 2.59
    Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis

    DOI: 10.1590/1414-431X20165594
    Sample: Plasma
  363. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020) IF: 2.614
    Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

    DOI: 10.1002/jsfa.10779
    Sample: Tissue homogenate
  364. Dose-Response (2022) IF: 2.623
    Dose Dependent Effects of Breynia cernua Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: In Vitro, In Vivo and Mechanistic Studies

    DOI: 10.1177/15593258221125478
    Sample: brain tissue
  365. Dose-Response (2022) IF: 2.623
    Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion :

    DOI: 10.1177/15593258221114184
    Sample: serum,Pancreatic,intestinal tissue
  366. Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
    Molecular Mechanism of Traditional Chinese Ointment of Xuzhou Qufu Shengji in Infected Wounds

    DOI: 10.1155/2022/4116563

    PMID: 35069758

    		 Sample: skin
  367. Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
    Etlingera elatior Flower Aqueous Extract Protects against Oxidative Stress-Induced Nephropathy in a Rat Model of Type 2 Diabetes

    DOI: 10.1155/2022/2814196

    PMID: 35502173

    		 Sample: kidney tissue
  368. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2018) IF: 2.673
    Orthosiphon stamineus (Misai Kucing) ameliorated postmenopausal osteoporosis in rat model

    DOI: 10.1097/GME.0000000000000980
    Sample: serum
  369. EXPERIMENTAL BIOLOGY AND MEDICINE (2020) IF: 2.691
    Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats:

    DOI: 10.1177/1535370220931038
    Sample: Tissue homogenate
  370. FEBS Open Bio (2021) IF: 2.693
    Salvinorin A inhibits ovalbumin-stimulated allergic rhinitis and RBL-2H3 cells degranulation

    DOI: 10.1002/2211-5463.13219

    PMID: 34092045

    		 Sample: RBL-2H5 cells
  371. Journal of Experimental Zoology Part A-Ecological and Integrative Physiology (2022) IF: 2.693
    Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains

    DOI: 10.1002/jez.2603
    Sample: brain
  372. INTERNATIONAL IMMUNOPHARMACOLOGY (2014) IF: 2.711
    Effects and mechanisms of Geniposide on rats with adjuvant arthritis

    DOI: 10.1016/j.intimp.2014.02.021
    Sample: Cell lysate
  373. INTERNATIONAL IMMUNOPHARMACOLOGY (2014) IF: 2.711
    Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis

    DOI: 10.1016/j.intimp.2014.11.017
    Sample: Cell culture supernatant
  374. JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 2.72
    Effect of coconut water and milk on heat stress-induced gastrointestinal tract dysmotility in rats: Role of oxidative stress and inflammatory response

    DOI: 10.1111/jfbc.14129

    PMID: 35298033

    		 Sample: stomach
  375. EUROPEAN JOURNAL OF PHARMACOLOGY (2016) IF: 2.73
    The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy

    DOI: 10.1016/j.ejphar.2016.06.042
    Sample: Serum
  376. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020) IF: 2.734
    Folate receptor-β targeted cholesterol-chitosan nanocarrier for treatment of rheumatoid arthritis: An animal study

    DOI: 10.1016/j.jddst.2020.101946
    Sample: serum
  377. PLoS One (2020) IF: 2.74
    Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

    DOI: 10.1371/journal.pone.0230657

    PMID: 32208438

    		 Sample: Serum
  378. FUNDAMENTAL & CLINICAL PHARMACOLOGY (2021) IF: 2.748
    Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis

    DOI: 10.1111/fcp.12718

    PMID: 34309069

    		 Sample: serum
  379. Pharmacological Reports (2020) IF: 2.754
    Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures

    DOI: 10.1007/s43440-020-00208-w

    PMID: 33377994

    		 Sample: Plasma
  380. FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020) IF: 2.754
    Ameliorative effect of Ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia‐induced experimental vascular cognitive impairment and dementia

    DOI: 10.1111/fcp.12610
    Sample: Tissue homogenate
  381. Pharmacological Reports (2020) IF: 2.754
    Agomelatine prevents indomethacin-induced gastric ulcer in rats

    DOI: 10.1007/s43440-019-00049-2
    Sample: gastric tissue
  382. BIOMEDICINE & PHARMACOTHERAPY (2017) IF: 2.759
    Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats

    DOI: 10.1016/j.biopha.2017.03.077
    Sample: Serum
  383. JOURNAL OF BIOMEDICAL SCIENCE (2015) IF: 2.763
    High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats

    DOI: 10.1186/s12929-015-0211-6
    Sample: Serum
  384. ANDROLOGIA (2021) IF: 2.775
    Cysteamine mitigates torsion/detorsion-induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model

    DOI: 10.1111/and.14243

    PMID: 34498746

    		 Sample: serum
  385. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018) IF: 2.776
    Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism

    DOI: 10.1016/j.etap.2018.05.009
    Sample: Serum
  386. Journal of Physiological Sciences (2022) IF: 2.781
    MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1

    DOI: 10.1186/s12576-022-00827-3

    PMID: 35148687

    		 Sample: serum
  387. NEUROCHEMICAL RESEARCH (2019) IF: 2.782
    Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats

    DOI: 10.1007/s11064-019-02767-8

    PMID: 30859436

    		 Sample: Tissue homogenate
  388. JOURNAL OF MEDICINAL FOOD (2021) IF: 2.786
    Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats

    DOI: 10.1089/jmf.2020.0189

    PMID: 33512269

    		 Sample: plasma
  389. PHYSIOLOGY & BEHAVIOR (2020) IF: 2.826
    Inhibition of the fatty acid amide hydrolase changes behaviors and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress

    DOI: 10.1016/j.physbeh.2020.113174

    PMID: 32966816

    		 Sample: Tissue homogenate
  390. JOURNAL OF NEUROIMMUNOLOGY (2019) IF: 2.832
    The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy

    DOI: 10.1016/j.jneuroim.2019.03.018

    PMID: 30952062

    		 Sample: Plasma
  391. ANAEROBE (2022) IF: 2.837
    The comparison of changes in fecal and mucosal microbiome in metabolic endotoxemia induced by a high-fat diet

    DOI: 10.1016/j.anaerobe.2022.102615

    PMID: 35850456

    		 Sample: serum,colon
  392. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2020) IF: 2.842
    Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats

    DOI: 10.2147/DMSO.S247844
    Sample: serum
  393. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2020) IF: 2.842
    Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats

    DOI: 10.2147/DMSO.S246743

    PMID: 32606875

    		 Sample: Serum
  394. Frontiers in Psychiatry (2020) IF: 2.849
    Studies on Haloperidol and Adjunctive α-Mangostin or Raw Garcinia mangostana Linn Pericarp on Bio-Behavioral Markers in an Immune-Inflammatory Model of Schizophrenia in Male Rats

    DOI: 10.3389/fpsyt.2020.00121
    Sample: plasma
  395. WOUND REPAIR AND REGENERATION (2019) IF: 2.85
    Effects of depression on healing and inflammatory responses of acute wounds in rats

    DOI: 10.1111/wrr.12726
    Sample: serum
  396. ACS Omega (2020) IF: 2.87
    Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

    DOI: 10.1021/acsomega.0c01670

    PMID: 32803042

    		 Sample: Serum
  397. 3 Biotech (2022) IF: 2.893
    Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats

    DOI: 10.1007/s13205-022-03233-z

    PMID: 35903285

    		 Sample: Kidney tissue
  398. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2019) IF: 2.895
    Rutin abrogates manganese—Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway

    DOI: 10.1016/j.jtemb.2019.01.014
    Sample: Tissue homogenate
  399. BIOSCIENCE REPORTS (2018) IF: 2.899
    Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

    DOI: 10.1042/BSR20180892

    PMID: 30232232

    		 Sample: Tissue homogenate
  400. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021) IF: 2.9
    Phenolics-Enriched Fraction of Pterospermum Lanceifolium Roxb. efficiently Reverses the Hepatocellular Carcinoma in NDEA-Induced HCC Rats

    DOI: 10.1080/01635581.2021.1922716

    PMID: 34018459

    		 Sample: Tissue homogenate
  401. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model:

    DOI: 10.1177/09603271211017611
    Sample: Tissue homogenate(brain)
  402. Future Microbiology (2020) IF: 2.907
    The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model

    DOI: 10.2217/fmb-2020-0005

    PMID: 32250184

    		 Sample: Serum
  403. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019) IF: 2.928
    Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

    DOI: 10.3892/ijmm.2019.4285
    Sample: serum
  404. DIGESTIVE DISEASES AND SCIENCES (2019) IF: 2.937
    Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis

    DOI: 10.1007/s10620-019-05892-0

    PMID: 31617131

    		 Sample: Serum
  405. INFLAMMATION (2019) IF: 2.939
    Protective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Rats

    DOI: 10.1007/s10753-019-01028-8
    Sample: colon tissue
  406. INFLAMMATION (2019) IF: 2.939
    Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions

    DOI: 10.1007/s10753-019-01123-w

    PMID: 31705353

    		 Sample: Serum
  407. Molecular Medicine Reports (2018) IF: 2.952
    Puerarin reduces ischemia/reperfusion-induced myocardial injury in diabetic rats via upregulation of vascular endothelial growth factor A/angiotensin-1 and suppression of apoptosis

    DOI: 10.3892/mmr.2018.8754
    Sample: plasma
  408. Molecular Medicine Reports (2021) IF: 2.952
    NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease

    DOI: 10.3892/mmr.2021.12035

    PMID: 33864663

    		 Sample: Cell
  409. JOURNAL OF CELLULAR BIOCHEMISTRY (2018) IF: 2.959
    MAPKs and NF‐κB‐mediated acrylamide‐induced neuropathy in rat striatum and human neuroblastoma cells SY5Y

    DOI: 10.1002/jcb.27671
    Sample: Tissue homogenate
  410. JOURNAL OF CELLULAR BIOCHEMISTRY (2018) IF: 2.959
    Exosomes derived from miR‐146a‐modified adipose‐derived stem cells attenuate acute myocardial infarction−induced myocardial damage via downregulation of early growth response factor 1

    DOI: 10.1002/jcb.27731
    Sample: Serum,Cell culture supernatant
  411. BIOLOGY OF REPRODUCTION (2019) IF: 2.96
    Changes in alpha-7 nicotinic acetylcholine receptor and macrophage polarization state participate in the regulation of cervical remodeling in pregnant rats

    DOI: 10.1093/biolre/ioz133
    Sample: Tissue homogenate
  412. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
    Protective effect of betulinic acid on Freund's complete adjuvant‐induced arthritis in rats

    DOI: 10.1002/jbt.22373
    Sample: serum,synovium
  413. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
    Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats

    DOI: 10.1002/jbt.22427
    Sample: Serum,Tissue homogenate
  414. CANCER CHEMOTHERAPY AND PHARMACOLOGY (2020) IF: 2.967
    The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats

    DOI: 10.1007/s00280-020-04060-w

    PMID: 32415349

    		 Sample: Serum,Tissue homogenate,Feces
  415. PHARMACEUTICAL BIOLOGY (2020) IF: 2.971
    Protective effect of apigenin magnesium complex on H2O2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells

    DOI: 10.1080/13880209.2020.1772840
    Sample: Cell culture supernatant
  416. JOURNAL OF ETHNOPHARMACOLOGY (2017) IF: 2.981
    Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats

    DOI: 10.1016/j.jep.2017.01.035
    Sample: Serum,Tissue homogenate
  417. PeerJ (2021) IF: 2.984
    Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model

    DOI: 10.7717/peerj.11264

    PMID: 33954056

    		 Sample: Plasma
  418. Journal of Ovarian Research (2020) IF: 2.989
    The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.

    DOI: 10.1186/s13048-020-00650-7
    Sample: Serum
  419. Cardiovascular Toxicology (2018) IF: 2.989
    Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation

    DOI: 10.1007/s12012-018-9449-z
    Sample: Serum
  420. Cardiovascular Toxicology (2018) IF: 2.989
    Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction

    DOI: 10.1007/s12012-018-9478-7
    Sample: plasma
  421. Annals of Surgical Treatment and Research (2019) IF: 1.181
    Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats

    DOI: 10.4174/astr.2019.97.6.271

    PMID: 31824881

    		 Sample: Serum,Tissue homogenate
  422. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β

    DOI: 10.3892/etm.2017.4505
    Sample: Serum
  423. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Astragalus polysaccharides combined with ibuprofen exhibit a therapeutic effect on septic rats via an anti‑inflammatory cholinergic pathway

    DOI: 10.3892/etm.2017.4865
    Sample: Plasma
  424. Journal of Burn Care & Research (2017) IF: 1.349
    Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Rat ModelProtective Effect of Epigallocatechin Gallate

    DOI: 10.1097/BCR.0000000000000501
    Sample: serum
  425. Acta Cirurgica Brasileira (2018) IF: 1.388
    Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

    DOI: 10.1590/s0102-865020180030000006
    Sample: Serum
  426. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity

    DOI: 10.3892/etm.2018.6683
    Sample: Tissue homogenate
  427. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway

    DOI: 10.3892/etm.2017.5599
    Sample: Serum
  428. ARQUIVOS DE NEURO-PSIQUIATRIA (2022) IF: 1.42
    Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats

    DOI: 10.1590/0004-282X-ANP-2021-0101

    PMID: 35239805

    		 Sample: brain tissue,serum
  429. PATHOLOGY RESEARCH AND PRACTICE (2018) IF: 1.466
    miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4

    DOI: 10.1016/j.prp.2018.08.024

    PMID: 30195636

    		 Sample: Cell culture supernatant
  430. Molecular Medicine Reports (2014) IF: 1.484
    Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo

    DOI: 10.3892/mmr.2014.2026
    Sample: myocardial tissues
  431. Natural Product Communications (2023) IF: 1.496
    Vanillic Acid Alleviates Right Ventricular Function in Rats With MCT-Induced Pulmonary Arterial Hypertension

    DOI: 10.1177/1934578X221148896
    Sample: serum
  432. Iranian Journal of Basic Medical Sciences (2018) IF: 1.514
    The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats

    DOI: 10.22038/IJBMS.2018.27510.6714
    Sample: Serum
  433. PEDIATRICS INTERNATIONAL (2021) IF: 1.524
    Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats

    DOI: 10.1111/ped.14917

    PMID: 34242458

    		 Sample: Lung，kidney
  434. ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery (2022) IF: 1.538
    Mucolytic and Antioxidant Effects of Intranasal Acetylcysteine Use on Acute Rhinosinusitis in Rats with an Acute Rhinosinusitis Model

    DOI: 10.1159/000524869

    PMID: 35661091

    		 Sample: nose,sinuses
  435. Molecular Medicine Reports (2015) IF: 1.554
    Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism

    DOI: 10.3892/mmr.2015.4425
    Sample: Serum
  436. Asian Journal of Surgery (2019) IF: 1.56
    Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid

    DOI: 10.1016/j.asjsur.2019.07.001

    PMID: 31345657

    		 Sample: Tissue homogenate
  437. MEDICAL SCIENCE MONITOR (2017) IF: 1.585
    Epigallocatechin Gallate Attenuates Hip Fracture-Induced Acute Lung Injury by Limiting Mitochondrial DNA (mtDNA) Release

    DOI: 10.12659/MSM.902477
    Sample: Bronchoalveolar Lavage Fluid
  438. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2016) IF: 1.617
    Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study

    DOI: 10.3109/08923973.2016.1173058
    Sample: Serum
  439. Journal of Oleo Science (2022) IF: 1.628
    Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress

    DOI: 10.5650/jos.ess22033

    PMID: 35965085

    		 Sample: liver
  440. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2018) IF: 1.632
    Effect of polysaccharides from Vitis vinifera L. on NF-κB/IκB-α signal pathway and inflammatory factors in Alzheimer's model rats

    DOI: 10.1080/13102818.2018.1464948
    Sample: Serum
  441. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

    DOI: 10.1111/jfbc.13359
    Sample: lung,liver,kidney
  442. Molecular Medicine Reports (2017) IF: 1.692
    Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway

    DOI: 10.3892/mmr.2017.6695
    Sample: Serum
  443. Molecular Medicine Reports (2017) IF: 1.692
    Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF in a rat model

    DOI: 10.3892/mmr.2017.7464
    Sample: intervertebral discs
  444. BIOLOGICAL & PHARMACEUTICAL BULLETIN (2018) IF: 1.694
    Qiliqiangxin Protects against Renal Injury in Rat with Cardiorenal Syndrome Type I through Regulating the Inflammatory and Oxidative Stress Signaling

    DOI: 10.1248/bpb.b17-00930

    PMID: 30068867

    		 Sample: Plasma
  445. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2022) IF: 1.762
    Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis

    DOI: 10.1080/13102818.2022.2116996
    Sample: serum
  446. MICROBIAL PATHOGENESIS (2015) IF: 1.794
    Candida glabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-κB

    DOI: 10.1016/j.micpath.2015.10.009
    Sample: Cell lysate
  447. Food Science & Nutrition (2020) IF: 1.797
    Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease

    DOI: 10.1002/fsn3.1952

    PMID: 33312544

    		 Sample: Cell culture supernatant
  448. Molecular Medicine Reports (2019) IF: 1.851
    MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways

    DOI: 10.3892/mmr.2019.10269
    Sample: serum
  449. Annals of Surgical Treatment and Research (2022) IF: 1.859
    Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats

    DOI: 10.4174/astr.2022.102.1.29

    PMID: 35071117

    		 Sample: colonic tissue
  450. Journal of Zhejiang University-SCIENCE B (2019) IF: 1.879
    Improvement in post-partum uterine involution in rats treated with Apios americana

    DOI: 10.1631/jzus.B1800475
    Sample: serum
  451. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2022) IF: 1.885
    Effect of oligosaccharides on the antioxidant, lipid and inflammatory profiles of rats with streptozotocin-induced diabetes mellitus

    DOI: 10.1515/znc-2021-0215
    Sample: serum
  452. PHARMACEUTICAL BIOLOGY (2018) IF: 1.918
    Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus

    DOI: 10.1080/13880209.2018.1504972
    Sample: serum
  453. MEDICAL SCIENCE MONITOR (2020) IF: 1.918
    Evaluation of 2 Rat Models for Sepsis Developed by Improved Cecal Ligation/Puncture or Feces Intraperitoneal-Injection

    DOI: 10.12659/MSM.919054

    PMID: 31992687

    		 Sample: Plasma
  454. Molecular Medicine Reports (2018) IF: 1.922
    Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats

    DOI: 10.3892/mmr.2017.8069
    Sample: hippocampus
  455. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2019) IF: 1.927
    Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue

    DOI: 10.1055/a-1023-6710

    PMID: 31683330

    		 Sample: Serum
  456. ANDROLOGIA (2020) IF: 1.951
    Carob attenuates nicotine-induced oxidative stress and intratesticular damage in male rats

    DOI: 10.1111/and.13670
    Sample: serum
  457. Toxicology Research (2017) IF: 1.969
    Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats

    DOI: 10.1039/C6TX00444J
    Sample: Tissue homogenate
  458. Current Research in Toxicology (2022)
    Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

    DOI: 10.1016/j.crtox.2022.100098
    Sample: ovarian,thyroid,thyroid cell
  459. Intensive Care Medicine Experimental (2019)
    Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

    DOI: 10.1186/s40635-019-0242-5
    Sample: blood
  460. International Journal of Fertility & Sterility (2022)
    Silver Nanoparticles Biofabricated from Cinnamomum zeylanicum Reduce IL-6, IL-18, and TNF-ɑ in Female Rats with Polycystic Ovarian Syndrome

    DOI: 10.22074/IJFS.2022.539396.1189
    Sample: serum
  461. Medical Science Monitor Basic Research (2022)
    Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma

    DOI: 10.12659/MSMBR.933726
    Sample: Adipose Tissue-Derived Mesenchymal Stem Cells (ATM
  462. Journal of Diabetes and Metabolic Disorders (2020)
    Polyphenolic-rich extracts of Andrographis paniculata mitigate hyperglycemia via attenuating β-cell dysfunction, pro-inflammatory cytokines and oxidative stress in alloxan-induced diabetic Wistar albino rat

    DOI: 10.1007/s40200-020-00690-2
    Sample: serum
  463. Turkish Journal of Pharmaceutical Sciences (2021)
    Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines

    DOI: 10.4274/tjps.galenos.2021.03271
    Sample: H4IIE cell,clone-9 cell
  464. Toxicology Reports (2023)
    Interactions of alcohol and combination antiretroviral (cART) drug in diabetic male Sprague Dawley rats: Hippocampal perturbations and toxicosis

    DOI: 10.1016/j.toxrep.2023.01.009
    Sample: brain
  465. Physiological Reports (2021)
    Inflammation-induced left ventricular fibrosis is partially mediated by tumor necrosis factor-α

    DOI: 10.14814/phy2.15062
    Sample: serum
  466. Heliyon (2021)
    Highly active antiretroviral therapy conjugated silver nanoparticle ameliorates testicular injury in type-2 diabetic rats

    DOI: 10.1016/j.heliyon.2021.e08580
    Sample: testicular tissue
  467. Journal of Diabetes and Metabolic Disorders (2023)
    Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes

    DOI: 10.1007/s40200-022-01178-x
    Sample: Liver tissue
  468. Advances in Traditional Medicine (2020)
    Anti-inflammatory activity of Xanthium indicum on carrageenan-induced paw edema in rats

    DOI: 10.1007/s13596-020-00502-1
    Sample: Tissue homogenate
  469. Journal of Diabetes and Metabolic Disorders (2021)
    Acetate supplementation restores testicular function by modulating Nrf2/PPAR-γ in high fat diet-induced obesity in Wistar rats

    DOI: 10.1007/s40200-021-00924-x
    Sample: testicular tissue
  470. International Journal of Clinical and Experimental Pathology (2020) IF: 0.252
    Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway

    PMID: 32509067

    		 Sample: serum
  471. Turkish Journal of Biochemistry-Turk Biyokimya Dergisi (2021) IF: 0.401
    The effects of vitamin D, fish oil and exercise on cardiovascular parameters in ovariectomized rats

    DOI: 10.1515/tjb-2021-0185
    Sample: serum
  472. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2020) IF: 0.504
    Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury

    DOI: 10.4314/tjpr.v19i7.14
    Sample: Serum
  473. INTERNATIONAL SURGERY (2018) IF: 0.576
    Protective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury

    DOI: 10.9738/INTSURG-D-15-00301.1
    Sample: colon tissue
  474. Acta Cirurgica Brasileira (2016) IF: 0.58
    Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats

    DOI: 10.1590/S0102-865020160070000004
    Sample: Serum
  475. RENAL FAILURE (2016) IF: 0.875
    Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats

    DOI: 10.1080/0886022X.2016.1184957
    Sample: Serum
  476. Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery (2022) IF: 0.894
    Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.

    DOI: 10.14744/tjtes.2021.90140
    Sample: Serum
  477. Turkish Journal Of Medical Sciences (2021) IF: 0.973
    Antiinflammatory effects of adalimumab, tocilizumab, and steroid on lipopolysaccharide-induced lung injury

    DOI: 10.3906/sag-2010-303
    Sample: bronchoalveolar lavage (BAL)
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Reviews/Q&A

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Q

SSSubmitted [ Oct 03 2022 ]

Asked: Does this work in supernatant from harvested rat brain samples?

Reply

A

adminSubmitted [ Oct 03 2022 ]

Answered: EL-R0015 kit is suitable for the detection of rat brain tissue samples. We have verified normal rat whole brain tissue undilution and the sample measured value was 20-100pg/mL. However, there are individual differences between samples, so it is suggested that you can confirm it through pre-experiment. In addition, it is not recommended to use special lysates when collecting tissue samples. In generall, the tissue samples can be collected as follows for ELISA assays. 1) Mince the tissues to small pieces as much as you can and rinse them in ice-cold PBS (0.01M, pH=7.4) to remove excess blood thoroughly. 2) Tissue pieces should be weighed and then homogenized in PBS (tissue weight (g): PBS volume (mL) =1:9) with a glass homogenizer on ice(It's suggested to add an appropriate amount of protease inhibitor to PBS before the homogenization). 3) To further break the cells, you can sonicate the suspension with an ultrasonic cell disrupter or subject it to freeze-thaw cycles. 4) The homogenates are then centrifuged for 5 minutes at 5000×g at 2 - 8℃, collect the supernatant to carry out the assay. To get more accurate result, it's suggested to run the assay with freshly collected samples.

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