E-Cadherin Polyclonal Antibody
- +1
Price: $ 380
Price: $ 230
Price: $ 125
Price: $ 65
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Rabbit
- Reactivity: Human
- Applications: IHC
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Product Details
Verified Samples |
Verified Samples in IHC:Human carcinoma of Colon,Human breast cancer,Human placenta |
Dilution |
IHC 1:100-1:400 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Recombinant Human Cadherin-1 protein |
Abbre | E-Cadherin |
Synonyms | Arc 1;CADH1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CAM 120/80;CD 324;CD324;CD324 antigen;cdh1;CDHE;E-Cad/CTF3;E-cadherin;ECAD;Epithelial cadherin;epithelial calcium dependant adhesion protein;LCAM;Liver cell adhesion molecule;UVO;Uvomorulin |
Swissprot | |
Cellular Localization | Cell junction. Cell membrane. Endosome. Golgi apparatus>trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
Concentration | 1 mg/mL |
Buffer | PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer; Developmental Biology; Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Biological ice pack at 4 ℃ |
background | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. |
Citations
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Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression
IF:4.38
Journal:Scientific Reports
DOI:10.1038/s41598-021-01192-8
PMID:34741083
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A novel long noncoding RNA, LOC440173, promotes the progression of esophageal squamous cell carcinoma by modulating the miR‐30d‐5p/HDAC9 axis and the epithelial–mesenchymal transition
IF:3.825
Journal:MOLECULAR CARCINOGENESIS
DOI:10.1002/mc.23264
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol