Recombinant Mouse β-Nerve Growth Factor/β-NGF (Ser122-Gly241) Protein

  • Recombinant protein products for various applications-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant protein products for various applications-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM041189

      Synonyms:Beta-nerve growth factor; Beta-NGF; Ngf

      Size:
      • 10 µg
      • 50 µg
      Qty:
      - +
      Price: $113

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      Overview

      Synonyms Beta-nerve growth factor; Beta-NGF; Ngf
      Species Mouse
      Expression_host E.coli
      Sequence Ser122-Gly241
      Accession P01139
      Mol_Mass 13.5 kDa
      AP_Mol_Mass 14 kDa
      Bio_Activity Measured in a cell proliferation assay using TF‑1 human erythroleukemic cellsThe ED50 for this effect is less than 2 ng/ml.

      Properties

      Purity >95% as determined by reducing SDS-PAGE.
      Endotoxin <1.0 EU per μg as determined by LAL test.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
      Shipping The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
      Reconstitution Please refer to it for detailed information.

      Background

      NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
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