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APOE (Apolipoprotein E) is the major apoprotein of chylomicron. It binds to specific liver and peripheral cell receptors, mediating the binding, internalization and catabolism of lipoprotein particles. It acts as a ligand for the LDL (apo-B / E) receptor as well as a ligand for liver-specific apo-E receptor (chylomicron remnants), and is essential for regulates the normal catabolism of triglyceride-rich lipoprotein components. Mutations in this gene result in familial dysbetalipoproteinemia or type III hyperlipoproteinemia (HLP III), in which elevated plasma cholesterol and triglycerides are a result of impaired clearance of chylomicron and VLDL residuals. The relevant pathways are statin pathway and metabolism.

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