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MTHFR (Methylenetetrahydrofolate Reductase) is capable of catalyzing the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for the re-methylation of homocysteine to methionine. The genetic variation of this gene affects the susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. The relevant pathways are folate-alcohol metabolism and cancer pathway.

MTHFR Polyclonal Antibody

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