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Tricarboxylic acid (TCA) cycle

The TCA cycle takes place in the mitochondria of the cell. Decarboxylation and dehydrogenation of Pyruvate are carried out by TCA cycle. The carboxyl group formed into CO2. The hydrogen atoms formed into H2O and release ATP under the oxidative phosphorylation with the NAD+ and FAD as carrier. In addition, TCA cycle is also a common pathway for oxidative decomposition of various fuel molecules, such as fatty acids and amino acids. The cycle begins with the condensation of Acetyl coenzyme A with Oxaloacetic acid to form Citric acid, which is catalyzed by citrate synthetase. Disorder of the TCA cycle, whether caused by disease state or sub-healthy body, can lead to a wide range of metabolic disorders and diseases. The TCA cycle can be described as follows:

TCA cycle