AKT1

AKT1 is a serine / threonine protein kinase that has three closely related family members (AKT1, AKT2 and AKT3) that are involved in a variety of biological processes including metabolism, proliferation, cell survival, growth, insulin signaling and angiogenesis, etc., that are all mediated by serine and/or threonine phosphorylation of a series of downstream substrates. AKT activation relies on the PI3K pathway and is considered as a key node in this pathway. Mutations in the AKT1 have also been demonstrated to confer resistance to allosteric kinase inhibitors in vitro. To date more than 100 substrate candidates for AKT1 have been reported. The relevant pathways are transcription androgen receptor nuclear signaling and E-cadherin signaling in keratinocytes.