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MAPK-ERK Signaling Pathway

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Ion Channels [Ca2+] [Ca2+] RTKs RTKs6 Integrins PLC γ shc RAS GRB2 GRB2 Rac Rap1 CRK RACK1 Pax Tal FRS2 IRS SOS Spry Spred SOS SOS CAS [cAMP] C3G EPAC Raptor mTOR Signaling Ca+2-regulated Exocytosis Migration Cytoplasmic Anchoring Cell Adhesion Late Endosome Ion Channels Receptors Translation Control Growth Differentitation Proliferation Transcription Src PKC MEK1 ERK1 ERK1/2 ERK1/2 MKP-1/2 PPAR-γ cdc25 MNK1/2 ERK1/2 MEK1/2 IGF2BP KSR 1/2 PP1/ PP2At 14-3-3 RPS6 elF4B TSC2 MKP-3 PEA-15 cPLA 2 LAMTOR2 MP1 p27 Bim WAVE-2 FLNA IκBα TCPβ PLD1 MSK1/2 P90RSK P90RSK P90RSK BUB1 YBX1 MITF Nur77 Erα c-Fos c-Fos Pax6 SRF ATF1 CREB FoxO3 TIF1A Elk-1 Ets ER UBF Stat1/3 c-Myc/ N-Myc Histone H3 ER81 HMGN1 ATF4 TIF1A ETV1 Myt1 Mad1 C/EBPβ GSK-3 eEF2K DAPK BAD nNos METTL1 c-TAK1 COT AMPK LKB1 Raf-1 Raf-1 Raf-B Raf-B PI3K PYK2 PAK PKA Fyn FAK Cytoplasm Nucleus