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Circadian Clock Genes



All living things, including humans, have a "clock" in the body that enables us to adapt to the circadian transformation and regulate life activities. Discoveries about how organisms stay in sync with Earth’s rhythm of day and night have won this year’s Nobel Prize in Physiology or Medicine.


Jeffrey Hall and Michael Rosbash of Brandeis University in Waltham, Massachusetts, and Michael Young of The Rockefeller University in New York City share the prize equally for their work on how several genes work together to control the basic circadian clock, encoding proteins that build up during the night and are broken down during the day. These clocks are ticking inside plants, fungi, protozoa, and animals. In recent years, researchers have found that the clock is related not only to our sleep cycle, but also to metabolism and brain function.


A. TIM protein encoded by the timeless gene can interact with PER protein which is essential to the negative feedback regulation of period transcription in the nucleus.

BDBT protein encoded by the doubletime gene is a protein kinase which can phosphorylates PER protein, and the phosphorylation will lead to the degradation and inactivation of PER, and finally result in the time difference between period mRNA and PER protein. CLK protein encoded by the clock gene and CYK protein encoded by the cycle gene are two of the transcription factors that activate the expression of period.


Transcription and translation of core clock components (CLOCK, NPAS2,ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period of the rhythm.


Elabscience® has selected a detailed catalogue of antibodies and ELISA kits related to the circadian clock genes. Click the links below and see what we can do for your research.


Cat. No.

Product Name

Reactivity

E-AB-30962

Clock Polyclonal Antibody

Human,mouse,rat

E-AB-33317

NPAS2 Polyclonal Antibody

Human,Rat

E-AB-30170

BMAL1 Polyclonal Antibody

Human,mouse,rat

E-AB-16700

PER2 Polyclonal Antibody

Human

E-AB-21217

Phospho-Per2 (Ser662) Polyclonal Antibody

Human,mouse

E-EL-H2250

Human CRY1(Cryptochrome 1) ELISA Kit

Human

E-EL-M0364

Mouse CRY1(Cryptochrome 1) ELISA Kit

Mouse

E-EL-R0282

Rat CRY1(Cryptochrome 1) ELISA Kit

Rat

E-EL-H5568

Human CRY2(Cryptochrome 2) ELISA Kit

Human