2017-12-01Author:adminpraise:1
EGFR (Epidermal Growth Factor Receptor) is a transmembrane glycoprotein that belongs to the member of the protein kinase superfamily. This protein is a receptor of the epidermal growth factor family and binds to it. Its binding to the ligand induces dimerization and tyrosine autophosphorylation and leads to cell proliferation. EGFR is widely recognized for its importance in cancer. Overexpression and mutation of proteins have proven to be the key to driving the development of many cancers. Its role in non-small cell lung cancer, glioblastoma and basal-like breast cancer has promoted the research and development of many related drugs. The relevant pathways are transcriptio androgen receptor nuclear signaling and arrhythmogenic right ventricular cardiomyopathy (ARVC).
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Human, Mouse, Rat, Monkey |
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