IL6

IL6 (Interleukin 6) encodes a cytokine that functions in inflammation and maturation of B cells with multiple biological functions. This protein is produced primarily at acute and chronic inflammatory sites where it is secreted into the serum and induces transcriptional inflammatory responses through interleukin 6 receptor alpha. Plays an important role in the final differentiation of B cells into immunoglobulin-secreting cells. Involved in lymphocytes and monocyte differentiation and plays a role in T cells, hepatocytes, hematopoietic progenitor cells and central nervous system cells. In addition, IL6 has been shown to be an endogenous pyrogen and can induce fever in people with autoimmune diseases or infections. The function of this gene involves a variety of inflammation-related diseases, including diabetes and systemic juvenile rheumatoid arthritis. Its related pathways are transcription androgen receptor nuclear signaling and hematopoietic cell lineage.