AATF Polyclonal Antibody

Uniprot: Q9NY61
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30907

      Synonyms:AATF,AATF,Apoptosis antagonizing transcription factor ,Apoptosis-antagonizing transcription factor,BFR2,CHE 1,CHE1,DED,Protein AATF,Rb binding protein Che 1,Rb-binding protein Che-1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AATF,AATF,Apoptosis antagonizing transcription factor ,Apoptosis-antagonizing transcription factor,BFR2,CHE 1,CHE1,DED,Protein AATF,Rb binding protein Che 1,Rb-binding protein Che-1
      Swissprot Q9NY61
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the N-terminal region of human Che-1
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus>nucleolus.
      Tissue specificity Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

      Images

      Western Blot analysis of Hela cells with AATF Polyclonal Antibody

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