ABL1 Polyclonal Antibody

Uniprot: P00519
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30710

      Synonyms:Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine protein kinase 1,Abl 1,ABL,ABL proto oncogene 1 non receptor tyrosine kinase,ABL1,ABL1,bcr/abl,bcr/c abl oncogene protein,c ABL,c abl oncogene 1 non receptor tyrosine kinase,c abl oncogene 1 receptor tyrosine kinase,c ABL1,JTK7,p150,Proto oncogene tyrosine protein kinase ABL1,Proto-oncogene c-Abl,Tyrosine-protein kinase ABL1,v abl Abelson murine leukemia viral oncogene homolog 1,v abl

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine protein kinase 1,Abl 1,ABL,ABL proto oncogene 1 non receptor tyrosine kinase,ABL1,ABL1,bcr/abl,bcr/c abl oncogene protein,c ABL,c abl oncogene 1 non receptor tyrosine kinase,c abl oncogene 1 receptor tyrosine kinase,c ABL1,JTK7,p150,Proto oncogene tyrosine protein kinase ABL1,Proto-oncogene c-Abl,Tyrosine-protein kinase ABL1,v abl Abelson murine leukemia viral oncogene homolog 1,v abl
      Swissprot P00519
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from human Abl1 around the non-phosphorylation site of Thr735.
      Application WB,ELISA
      Recommended dilution WB 1:500-1:2000, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear.
      Tissue specificity Widely expressed.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. 

      Images

      Western Blot analysis of COS-7 cells using Abl1 Polyclonal Antibody at dilution of 1:2000.

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