ALKBH1 Polyclonal Antibody

Uniprot : Q13686
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14463

      Synonyms:ABH,ABH1,alkB,alkB homolog 1 histone H2A dioxygenase,AlkB,alkylation repair homolog 1 (E. coli),ALKB1,ALKBH,ALKBH1,Alkylated DNA repair protein alkB homolog 1,Alkylation repair homolog 1,Alkylation repair,alkB homolog,Alpha-ketoglutarate-dependent dioxygenase ABH1,DNA lyase ABH1,DNA oxidative demethylase ALKBH1,hABH

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms ABH,ABH1,alkB,alkB homolog 1 histone H2A dioxygenase,AlkB,alkylation repair homolog 1 (E. coli),ALKB1,ALKBH,ALKBH1,Alkylated DNA repair protein alkB homolog 1,Alkylation repair homolog 1,Alkylation repair,alkB homolog,Alpha-ketoglutarate-dependent dioxygenase ABH1,DNA lyase ABH1,DNA oxidative demethylase ALKBH1,hABH
      Swissprot Q13686
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human ALKBH1
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:200-1:1000
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Mitochondrion. Nucleus. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli.
      Tissue specificity Ubiquitous.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.

      Images

      Western Blot analysis of Mouse pancreas tissue using ALKBH1 Polyclonal Antibody at dilution of 1:250

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