APC Polyclonal Antibody

Uniprot : P25054

Catalog number:E-AB-30520

Synonyms:Adenomatous Polyposis Coli,Adenomatous polyposis coli protein,Apc,APC,CC1,Deleted in polyposis 2.5,DP2,DP2.5,DP3,FAP,FPC,GS,Protein APC

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Price: $69

Host: Rabbit

Reactivity: H,M,R

Applications: WB,IHC-p,IF,ELISA

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Synonyms	Adenomatous Polyposis Coli,Adenomatous polyposis coli protein,Apc,APC,CC1,Deleted in polyposis 2.5,DP2,DP2.5,DP3,FAP,FPC,GS,Protein APC
Swissprot	P25054
Source	Rabbit
Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from the C-terminal region of human APC
Application	WB,IHC-p,IF,ELISA
Recommended dilution	WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Concentration	1mg/mL
Clonality	Polyclonal

Cellular localization	Cell junction>adherens junction. Cytoplasm>cytoskeleton. Cell projection>lamellipodium. Cell projection>ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Tissue specificity	Expressed in a variety of tissues.
Isotype	IgG
Purification	Affinity purification
Conjugation	Unconjugated
Storage instructions	Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background	This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.