Current Position:Home>>Antibodies>>Polyclonal Antibody>> APC Polyclonal Antibody
Catalog number:E-AB-30520
Synonyms:Adenomatous Polyposis Coli,Adenomatous polyposis coli protein,Apc,APC,CC1,Deleted in polyposis 2.5,DP2,DP2.5,DP3,FAP,FPC,GS,Protein APC
Host: Rabbit
Reactivity: H,M,R
Applications: WB,IHC-p,IF,ELISA
Synonyms | Adenomatous Polyposis Coli,Adenomatous polyposis coli protein,Apc,APC,CC1,Deleted in polyposis 2.5,DP2,DP2.5,DP3,FAP,FPC,GS,Protein APC |
Swissprot | P25054 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | Synthesized peptide derived from the C-terminal region of human APC |
Application | WB,IHC-p,IF,ELISA |
Recommended dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000 |
Concentration | 1mg/mL |
Clonality | Polyclonal |
Cellular localization | Cell junction>adherens junction. Cytoplasm>cytoskeleton. Cell projection>lamellipodium. Cell projection>ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. |
Tissue specificity | Expressed in a variety of tissues. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Background | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |