ARC Polyclonal Antibody

Uniprot : Q7LC44
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14600

      Synonyms:activity regulated cytoskeleton associated protein,activity regulated gene 3.1 protein homolog,Activity-regulated cytoskeleton-associated protein,Activity-regulated gene 3.1 protein homolog,Arc,ARC/ARG3.1,ARC,Arg3.1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms activity regulated cytoskeleton associated protein,activity regulated gene 3.1 protein homolog,Activity-regulated cytoskeleton-associated protein,Activity-regulated gene 3.1 protein homolog,Arc,ARC/ARG3.1,ARC,Arg3.1
      Swissprot Q7LC44
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human ARC
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:50-1:200
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton. Endosome. Cytoplasmic vesicle>secretory vesicle>acrosome. Cell junction>synapse>postsynaptic cell membrane>postsynaptic density. Cell projection>dendrite. Cell projection>dendritic spine. Cell junction>synapse. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.

      Images

      Western Blot analysis of Mouse brain tissue using ARC Polyclonal Antibody at dilution of 1:597

      Immunohistochemistry of paraffin-embedded Human colon cancer using ARC Polyclonal Antibody at dilution of 1:50

      Immunohistochemistry of paraffin-embedded Human liver cancer using ARC Polyclonal Antibody at dilution of 1:50

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