AURKA Polyclonal Antibody

Uniprot: O14965
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30557

      Synonyms:AIK,ARK-1,ARK1,AURA,Aurka,Aurora 2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1 like kinase,Aurora/IPL1-related kinase 1,AURORA2,Breast tumor-amplified kinase,BTAK,hARK1,IAK,IPL1 related kinase,MGC34538,OTTHUMP00000031340,OTTHUMP00000031341,OTTHUMP00000031342,OTTHUMP00000031343,OTTHUMP00000031344,OTTHUMP00000031345,OTTHUMP00000166071,OTTHUMP00000166072,PPP1R47,Protein phosphatase 1,regulatory subunit 47,Serine/threonine kinase 15,Serine/threonine kinase 6,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,STK15,STK6,STK6,STK7

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms AIK,ARK-1,ARK1,AURA,Aurka,Aurora 2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1 like kinase,Aurora/IPL1-related kinase 1,AURORA2,Breast tumor-amplified kinase,BTAK,hARK1,IAK,IPL1 related kinase,MGC34538,OTTHUMP00000031340,OTTHUMP00000031341,OTTHUMP00000031342,OTTHUMP00000031343,OTTHUMP00000031344,OTTHUMP00000031345,OTTHUMP00000166071,OTTHUMP00000166072,PPP1R47,Protein phosphatase 1,regulatory subunit 47,Serine/threonine kinase 15,Serine/threonine kinase 6,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,STK15,STK6,STK6,STK7
      Swissprot O14965
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from human ARK-1 around the non-phosphorylation site of Ser342.
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton>centrosome. Cytoplasm>cytoskeleton>spindle pole. Detected at the neurite hillock in developing neurons (By similarity). Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
      Tissue specificity Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

      Images

      Western Blot analysis of COS7 cells with AURKA Polyclonal Antibody

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