ATF1 Polyclonal Antibody

Uniprot : P18846
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-17684

      Synonyms:TREB36,EWS-ATF1,FUS/ATF-1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms TREB36,EWS-ATF1,FUS/ATF-1
      Swissprot P18846
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthetic peptide of human ATF1
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-100, ELISA 1:2000-5000
      Concentration 1.1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

      Images

      Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ATF1 Polyclonal Antibody at dilution 1:35

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ATF1 Polyclonal Antibody at dilution 1:35

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