ATM Monoclonal Antibody

Uniprot : Q13315
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22251

      Synonyms:A-T mutated,A-T mutated homolog,AT mutated,AT1,ATA,Ataxia telangiectasia mutated,Ataxia telangiectasia mutated gene,Ataxia telangiectasia mutated homolog (human),Ataxia telangiectasia mutated homolog,ATC,ATD,ATDC,ATE,ATM,ATM serine/threonine kinase,ATM,DKFZp781A0353,MGC74674,OTTHUMP00000232981,Serine protein kinase ATM,Serine-protein kinase ATM,Serine/threonine-protein kinase ATM,Tefu,TEL1,TEL1,telomere maintenance 1,homolog,TELO1,Telomere fusion protein

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms A-T mutated,A-T mutated homolog,AT mutated,AT1,ATA,Ataxia telangiectasia mutated,Ataxia telangiectasia mutated gene,Ataxia telangiectasia mutated homolog (human),Ataxia telangiectasia mutated homolog,ATC,ATD,ATDC,ATE,ATM,ATM serine/threonine kinase,ATM,DKFZp781A0353,MGC74674,OTTHUMP00000232981,Serine protein kinase ATM,Serine-protein kinase ATM,Serine/threonine-protein kinase ATM,Tefu,TEL1,TEL1,telomere maintenance 1,homolog,TELO1,Telomere fusion protein
      Swissprot Q13315
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant Protein of ATM of ATM
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
      Tissue specificity Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
      Clone No. Clone:1D1
      Isotype IgG
      Purification Protein A purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue using ATM Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using ATM Monoclonal Antibody at dilution of 1:200.

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