Current Position:Home>>Antibodies>>Polyclonal Antibody>> ACLY Polyclonal Antibody
Catalog number:E-AB-30607
Synonyms:ACL,Acly,ACLY,ATP citrate (pro-S) lyase,ATP citrate lyase,ATP citrate synthase,ATP-citrate (pro-S-)-lyase,ATP-citrate synthase,ATPcitrate synthase,ATPCL,Citrate cleavage enzyme,CLATP,OTTHUMP00000164773
Host: Rabbit
Reactivity: H,M,R,Mk
Applications: WB,IF,ELISA
Synonyms | ACL,Acly,ACLY,ATP citrate (pro-S) lyase,ATP citrate lyase,ATP citrate synthase,ATP-citrate (pro-S-)-lyase,ATP-citrate synthase,ATPcitrate synthase,ATPCL,Citrate cleavage enzyme,CLATP,OTTHUMP00000164773 |
Swissprot | P53396 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat,Monkey |
Immunogen | Synthesized peptide derived from human ATP-citrate synthase around the non-phosphorylation site of Ser455. |
Application | WB,IF,ELISA |
Recommended dilution | WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:10000 |
Concentration | 1mg/mL |
Clonality | Polyclonal |
Cellular localization | Cytoplasm. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Background | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. |