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BAP1 Polyclonal Antibody

Cat:E-AB-52177 Citations (1)
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human; Mouse; Rat
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human esophagus cancer,Human breast cancer
Dilution

IHC 1:40-1:200

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Fusion protein of human BAP1
Abbre BAP1
Synonyms BAP 1;Bap1;BAP1;BRCA 1 associated protein 1;BRCA1 associated protein 1;BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase);BRCA1-associated protein 1;Cerebral protein 13;Cerebral protein 6;DKFZp686N04275;FLJ35406;FLJ37180;HUCEP 13;Hucep 6;HUCEP13;Hucep6;KIAA0272;TPDS;Ubiquitin carboxy terminal hydrolase;Ubiquitin carboxyl terminal hydrolase BAP 1;Ubiquitin carboxyl terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase BAP1;UCHL2
Swissprot
Cellular Localization Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.
Concentration 0.8 mg/mL
Buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification Method Antigen affinity purification
Research Areas Cancer; Cell Biology; Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.