BCAS2 Polyclonal Antibody

Uniprot : O75934
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14784

      Synonyms:bcas2,Breast carcinoma amplified sequence 2,Breast carcinoma-amplified sequence 2,DAM1,DNA amplified in mammary carcinoma 1 protein,MGC7712,Pre mRNA splicing factor SPF27,Pre-mRNA-splicing factor spf27,Snt309,SPF27,SPF27,Spliceosome associated protein amplified in breast cancer,Spliceosome associated protein SPF 27,Spliceosome-associated protein SPF 27

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms bcas2,Breast carcinoma amplified sequence 2,Breast carcinoma-amplified sequence 2,DAM1,DNA amplified in mammary carcinoma 1 protein,MGC7712,Pre mRNA splicing factor SPF27,Pre-mRNA-splicing factor spf27,Snt309,SPF27,SPF27,Spliceosome associated protein amplified in breast cancer,Spliceosome associated protein SPF 27,Spliceosome-associated protein SPF 27
      Swissprot O75934
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human BCAS2
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:200-1:1000, IHC 1:50-1:200
      Concentration 0.5 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus>nucleolus.
      Tissue specificity Ubiquitously expressed.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TR∫ (thyroid hormone receptor beta), ERå (estrogen receptor alpha), ER∫, PR (progesterone receptor), and PPAR© (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.

      Images

      Western Blot analysis of A172 and 231 cell using BCAS2 Polyclonal Antibody at dilution of 1:250

      Immunohistochemistry of paraffin-embedded Human colon cancer using BCAS2 Polyclonal Antibody at dilution of 1:50

      Immunohistochemistry of paraffin-embedded Human lung cancer using BCAS2 Polyclonal Antibody at dilution of 1:50

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