BLNK Polyclonal Antibody

Uniprot: Q8WV28
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30652

      Synonyms:AGM4,B cell adapter containing SH2 domain protein,B cell adapter containing Src homology 2 domain protein,B cell adaptor containing SH2 domain,B cell linker,B cell linker protein,B cell-specific adaptor protein,B-cell activation,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BASH,Bca,BLNK,BLNK s,BLNK,Cytoplasmic adapter protein,Ly 57,Ly57,Lymphocyte antigen 57,Lyw 57,Lyw57,MGC111051,SH2 domain-containing leukocyte protein,65-KD,SLP 65,SLP-65,SLP65,Src homology [SH2] domain-containing leukocyte protein of 65 kD,Src homology 2 domain containing leukocyte protein of 65 kDa,Src homology 2 domain-containing leukocyte protein of 65 kDa

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AGM4,B cell adapter containing SH2 domain protein,B cell adapter containing Src homology 2 domain protein,B cell adaptor containing SH2 domain,B cell linker,B cell linker protein,B cell-specific adaptor protein,B-cell activation,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,B-cell linker protein,BASH,Bca,BLNK,BLNK s,BLNK,Cytoplasmic adapter protein,Ly 57,Ly57,Lymphocyte antigen 57,Lyw 57,Lyw57,MGC111051,SH2 domain-containing leukocyte protein,65-KD,SLP 65,SLP-65,SLP65,Src homology [SH2] domain-containing leukocyte protein of 65 kD,Src homology 2 domain containing leukocyte protein of 65 kDa,Src homology 2 domain-containing leukocyte protein of 65 kDa
      Swissprot Q8WV28
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from human BLNK around the non-phosphorylation site of Y96.
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Cell membrane. BCR activation results in the translocation to membrane fraction.
      Tissue specificity Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.

      Images

      Western Blot analysis of HuvEc cells with BLNK Polyclonal Antibody.

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