Synonyms:BMP-8,BMP-8B,BMP8,Bmp8b,BMP8B,bone morphogenetic protein 8 (osteogenic protein 2),Bone morphogenetic protein 8,Bone morphogenetic protein 8B,dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)),OP-2,OP2,Osteogenic protein 2
|Synonyms||BMP-8,BMP-8B,BMP8,Bmp8b,BMP8B,bone morphogenetic protein 8 (osteogenic protein 2),Bone morphogenetic protein 8,Bone morphogenetic protein 8B,dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)),OP-2,OP2,Osteogenic protein 2|
|Immunogen||Synthesized peptide derived from the Internal region of human BMP-8B|
|Recommended dilution||WB 1:500-1:2000, ELISA 1:40000|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.|
|Background||This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.BMP8B (Bone Morphogenetic Protein 8b) is a Protein Coding gene. Diseases associated with BMP8B include Achondroplasia and Blue Color Blindness. Among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is BMP8A.|
Western Blot analysis of 293 cells using BMP8B Polyclonal Antibody at dilution of 1:2000.