ARID4B Polyclonal Antibody

Uniprot: Q4LE39
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30670

      Synonyms:ARID 4B,ARID domain-containing protein 4B,ARID4B,AT rich interactive domain 4B (Rbp1 like),AT rich interactive domain 4B,BCAA,BRCAA 1,BRCAA1,Breast cancer associated antigen 1,Breast cancer associated antigen BRCAA 1,Breast cancer associated antigen BRCAA1,Breast carcinoma associated antigen,DKFZp313M2420,Histone deacetylase complex subunit SAP180,MGC163290,Rb binding protein homolog,RBBP1 L1,RBBP1L1,Rbp 1 like,Rbp1 l1,Rbp1 like,RBP1 like protein,RBP1L,Rbp1l1,Retinoblastoma binding protein 1 like 1,SAP 180,SAP180,SIN3A associated protein 180

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms ARID 4B,ARID domain-containing protein 4B,ARID4B,AT rich interactive domain 4B (Rbp1 like),AT rich interactive domain 4B,BCAA,BRCAA 1,BRCAA1,Breast cancer associated antigen 1,Breast cancer associated antigen BRCAA 1,Breast cancer associated antigen BRCAA1,Breast carcinoma associated antigen,DKFZp313M2420,Histone deacetylase complex subunit SAP180,MGC163290,Rb binding protein homolog,RBBP1 L1,RBBP1L1,Rbp 1 like,Rbp1 l1,Rbp1 like,RBP1 like protein,RBP1L,Rbp1l1,Retinoblastoma binding protein 1 like 1,SAP 180,SAP180,SIN3A associated protein 180
      Swissprot Q4LE39
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the Internal region of human BRCAA1.
      Application WB,ELISA
      Recommended dilution WB 1:500-1:2000, ELISA 1:10000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasmic and Nuclear
      Tissue specificity Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.ARID4B (AT-Rich Interaction Domain 4B) is a Protein Coding gene. Diseases associated with ARID4B include Breast Cancer. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription regulatory region DNA binding. An important paralog of this gene is ARID4A.

      Images

      Western Blot analysis of HuvEc cells with ARID4B Polyclonal Antibody

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