BUB1B Polyclonal Antibody

Uniprot: O60566
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30683

      Synonyms:Beta homolg of S. cerevisiae BUB 1,Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles,BUB 1B,BUB1 budding uninhibited by benzimidazoles 1 homolog beta,Bub1A,BUB1B,BUB1B,BUB1beta,BUBR1,Budding Uninhibited by Benzimidazoles 1 beta,Budding uninhibited by benzimidazoles 1 homolog beta (yeast),hBUBR1,MAD3/BUB1 related protein kinase,MAD3/BUB1-related protein kinase,MAD3L,Mitotic checkpoint gene BUB1B,Mitotic checkpoint kinase MAD3L,Mitotic checkpoint serine/threonine protein kinase BUB1 beta,Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,MVA1,OTTHUMP00000160319,Protein SSK1,SSK 1,SSK1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Beta homolg of S. cerevisiae BUB 1,Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles,BUB 1B,BUB1 budding uninhibited by benzimidazoles 1 homolog beta,Bub1A,BUB1B,BUB1B,BUB1beta,BUBR1,Budding Uninhibited by Benzimidazoles 1 beta,Budding uninhibited by benzimidazoles 1 homolog beta (yeast),hBUBR1,MAD3/BUB1 related protein kinase,MAD3/BUB1-related protein kinase,MAD3L,Mitotic checkpoint gene BUB1B,Mitotic checkpoint kinase MAD3L,Mitotic checkpoint serine/threonine protein kinase BUB1 beta,Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,MVA1,OTTHUMP00000160319,Protein SSK1,SSK 1,SSK1
      Swissprot O60566
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from the Internal region of human BubR1
      Application WB,ELISA
      Recommended dilution WB 1:500-1:2000, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.
      Tissue specificity Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background The Mitotic Checkpoint Complex (MCC), which contains Bub1, Bub1b, Bub3, Mad2, and Cdc20, controls chromosome segregation and monitors kinetochore-microtubule interactions (1). During mitosis, the MCC complex inhibits the ubiquitin ligase activity of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby preventing cells with unaligned chromosomes from prematurely entering anaphase (2). Research studies have shown that Bub1b and Bub1 kinases are mutated in several types of human malignancies including hematopoietic, colorectal, lung, and breast cancers (3). Biallelic mutations in Bub1b have been found in mosaic variegated aneuploidy syndrome and premature chromatid separation syndrome (4). Bub1b mouse germline knockouts are embryonic lethal with heterozygous animals displaying genetic instability, early aging phenotypes, and increased cancer susceptibility (5). Bub3 binds both Bub1 and Bub1b, facilitating their recruitment to kinetochores (6), and is required for functional microtubule-kinetochore interactions (7).

      Images

      Western Blot analysis of Hela cells with BUB1B Polyclonal Antibody

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