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C14orf169 Polyclonal Antibody

Cat:E-AB-17743
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human; Mouse; Rat
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human lung cancer
Dilution

IHC 1:30-1:150

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human C14orf169
Abbre C14orf169
Synonyms 60S ribosomal protein L8 histidine hydroxylase;C14orf169;Chromosome 14 open reading frame 169 ;Histone lysine demethylase NO66;hsNO66;Hypothetical protein FLJ21802;Lysine-specific demethylase NO66;MAPJD;MYC associated protein with JmjC domain;NO66;NO66;Nucleolar protein 66;Ribosomal oxygenase NO66;ROX;Up regulated in lung cancer 2;URLC2
Swissprot
Cellular Localization Nucleus>nucleolus. Nucleus>nucleoplasm. Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
Concentration 0.8 mg/mL
Buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.