c-Kit Polyclonal Antibody

Uniprot : P10721
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30933

      Synonyms:C Kit,c-Kit,c-Kit Ligand,CD117,Kit,Kit Ligand,KIT oncogene,KIT proto oncogene receptor tyrosine kinase,KIT,Mast cell growth factor receptor,Mast/stem cell growth factor receptor Kit,MGF,p145 c-kit,PBT,Piebald trait protein,Proto oncogene c Kit,Proto oncogene tyrosine protein kinase Kit,Proto-oncogene c-Kit,SCF Receptor,SCFR,soluble KIT variant 1,Steel Factor Receptor,Stem cell factor receptor,tyrosine protein kinase Kit,Tyrosine-protein kinase Kit,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms C Kit,c-Kit,c-Kit Ligand,CD117,Kit,Kit Ligand,KIT oncogene,KIT proto oncogene receptor tyrosine kinase,KIT,Mast cell growth factor receptor,Mast/stem cell growth factor receptor Kit,MGF,p145 c-kit,PBT,Piebald trait protein,Proto oncogene c Kit,Proto oncogene tyrosine protein kinase Kit,Proto-oncogene c-Kit,SCF Receptor,SCFR,soluble KIT variant 1,Steel Factor Receptor,Stem cell factor receptor,tyrosine protein kinase Kit,Tyrosine-protein kinase Kit,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
      Swissprot P10721
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from human c-Kit around the non-phosphorylation site of Tyr936.
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cell membrane and Cytoplasm. Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
      Tissue specificity Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

      Images

      Western Blot analysis of 453 cells using c-Kit Polyclonal Antibody at dilution of 1:500.

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