CA12 Polyclonal Antibody

Uniprot: O43570
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30704

      Synonyms:CA 12,CA XII,CA-XII,CA12,CAH12,Carbonate dehydratase XII,Carbonic anhydrase 12,Carbonic anhydrase XII,Carbonic dehydratase,CAXII,FLJ20151,HsT18816,T18816,Tumor antigen HOM RCC 3.1.3,Tumor antigen HOM-RCC-3.1.3

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CA 12,CA XII,CA-XII,CA12,CAH12,Carbonate dehydratase XII,Carbonic anhydrase 12,Carbonic anhydrase XII,Carbonic dehydratase,CAXII,FLJ20151,HsT18816,T18816,Tumor antigen HOM RCC 3.1.3,Tumor antigen HOM-RCC-3.1.3
      Swissprot O43570
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the Internal region of human CA XII
      Application WB,ELISA
      Recommended dilution WB 1:500-1:2000, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Membrane.
      Tissue specificity Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. CA12 (Carbonic Anhydrase 12) is a Protein Coding gene. Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Renal Cell Carcinoma. Among its related pathways are Nitrogen metabolism and Translational Control. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

      Images

      Western Blot analysis of NIH-3T3, 293T cells using CA12 Polyclonal Antibody at dilution of 1:2000.

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