Cadherin-Catenin Antibody Sampler Kit

    • Cadherin-Catenin Antibody Sampler Kit -Elabscience
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    • Cadherin-Catenin Antibody Sampler Kit -Elabscience
    • Cadherin-Catenin Antibody Sampler Kit -Elabscience

      Catalog number:E-AB-K1457

      Size:
      • 5*20μL
      Qty:
      - +
      Price: $310

      Applications: WB

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      Product Includes

      Product name Specifications Application
      Catenin alpha 1/2 Polyclonal Antibody 20μL WB,IHC-p,IF,ELISA
      N-Cadherin Polyclonal Antibody 20μL WB,IHC-p,IF,ELISA
      E-Cadherin Polyclonal Antibody 20μL WB,IHC-p,IF,ELISA
      P-Cadherin Polyclonal Antibody 20μL WB,IHC-p,ELISA
      Catenin beta Polyclonal Antibody 20μL WB,IHC-p,IF,ELISA
      Goat Anti-Rabbit IgG (H+L)(peroxidase/HRP conjugated) 120μL WB,IHC,ELISA

      Product Photos

      Western Blot analysis of Hela cells using Catenin alpha 1/2 Polyclonal Antibody at dilution of 1:500.

      Western Blot analysis of Jurkat cells using N-cadherin Polyclonal Antibody at dilution of 1:1000.

      Western Blot analysis of various cells using E-cadherin Polyclonal Antibody at dilution of 1:1000.

      Western Blot analysis of K562 cells with P-cadherin Polyclonal Antibody.

      Western Blot analysis of 823 cells using Catenin beta Polyclonal Antibody at dilution of 1:2000.

      Product description

      This Cadherin-Catenin Antibody Sampler kit contains reagents to examine the total protein levels of key proteins found in cell-cell adherens junctions. The kit contains enough primary and secondary antibodies to perform two Western blot experiments.

      Background

      Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of cadherins that are transmembrane proteins that bind cadherins on adjacent cells in a calcium dependent manner. On the cytoplasmic side of adherens junctions, the cadherins associate with β-catenin, γ-catenin and p120 catenin (δ). β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton. Recent studies indicate that cancer cells exhibit increased N-cadherin and diminished E-cadherin expression. E-cadherin is considered a suppressor of invasive cancer cell growth and this change in cadherin expression associated with cancer progression is termed the “cadherin switch”. β-catenin is one of the key downstream effectors in the Wnt signaling pathway and has been implicated in early embryonic development and tumorigenesis.

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