CALR Polyclonal Antibody

Uniprot: P27797
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30729

      Synonyms:Autoantigen RO,CALR,CALR protein,CALR,Calregulin,Calreticulin,cC1qR,CRP55,CRT,CRTC,Endoplasmic reticulum resident protein 60,Epididymis secretory sperm binding protein Li 99n,ERp60,FLJ26680,grp60,HACBP,HEL S 99n,RO,Sicca syndrome antigen A (autoantigen Ro,calreticulin),Sicca syndrome antigen A,SSA

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms Autoantigen RO,CALR,CALR protein,CALR,Calregulin,Calreticulin,cC1qR,CRP55,CRT,CRTC,Endoplasmic reticulum resident protein 60,Epididymis secretory sperm binding protein Li 99n,ERp60,FLJ26680,grp60,HACBP,HEL S 99n,RO,Sicca syndrome antigen A (autoantigen Ro,calreticulin),Sicca syndrome antigen A,SSA
      Swissprot P27797
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from the N-terminal region of human Calregulin
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Endoplasmic reticulum lumen. Cytoplasm>cytosol. Secreted>extracellular space>extracellular matrix. Cell surface. Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

      Images

      Western Blot analysis of COS7 cells with CALR Polyclonal Antibody

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