Current Position:Home>>Antibodies>>Polyclonal Antibody>> Catenin alpha 1/2 Polyclonal Antibody
Catalog number:E-AB-30763
Synonyms:CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein
Host: Rabbit
Reactivity: H,M,R
Applications: WB,IHC-p,IF,ELISA
Synonyms | CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein |
Swissprot | P35221,P26232 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | Synthesized peptide derived from the C-terminal region of human Catenin-α E/N |
Application | WB,IHC-p,IF,ELISA |
Recommended dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000 |
Concentration | 1mg/mL |
Clonality | Polyclonal |
Cellular localization | Cytoskeleton,actin cytoskeleton,Cytosol,Golgi apparatus,Golgi apparatus,Plasma Membrane,catenin complex,flotillin complex,plasma membrane,Other locations:acrosomal vesicle,cell junction,cell-cell junction,focal adhesion,intercalated disc,intracellular membrane-bounded organelle,lamellipodium,zonula adherens |
Tissue specificity | Expressed ubiquitously in normal tissues. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Background | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |