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Catenin alpha 1/2 Polyclonal Antibody
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Catalog number:E-AB-30763
Synonyms:CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein
Size:
- 20 μL
- 60 μL
- 120 μL
- 200 μL
Qty:
-
+
Price:
$69
Host: Rabbit
Reactivity: H,M,R
Applications: WB,IHC-p,IF,ELISA
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Overview
| Synonyms | CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein |
| Swissprot | P35221,P26232 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Catenin-α E/N |
| Application | WB,IHC-p,IF,ELISA |
| Recommended dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoskeleton,actin cytoskeleton,Cytosol,Golgi apparatus,Golgi apparatus,Plasma Membrane,catenin complex,flotillin complex,plasma membrane,Other locations:acrosomal vesicle,cell junction,cell-cell junction,focal adhesion,intercalated disc,intracellular membrane-bounded organelle,lamellipodium,zonula adherens |
| Tissue specificity | Expressed ubiquitously in normal tissues. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Background | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
Images
Western Blot analysis of Hela cells using Catenin alpha 1/2 Polyclonal Antibody at dilution of 1:500.
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