Catenin alpha 1/2 Polyclonal Antibody

Uniprot: P35221,P26232
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30763

      Synonyms:CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein
      Swissprot P35221,P26232
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the C-terminal region of human Catenin-α E/N
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoskeleton,actin cytoskeleton,Cytosol,Golgi apparatus,Golgi apparatus,Plasma Membrane,catenin complex,flotillin complex,plasma membrane,Other locations:acrosomal vesicle,cell junction,cell-cell junction,focal adhesion,intercalated disc,intracellular membrane-bounded organelle,lamellipodium,zonula adherens
      Tissue specificity Expressed ubiquitously in normal tissues.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

      Images

      Western Blot analysis of Hela cells using Catenin alpha 1/2 Polyclonal Antibody at dilution of 1:500.

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