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Catenin alpha 1/2 Polyclonal Antibody

Catalog number:E-AB-30763

Synonyms:CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein

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20 μL
60 μL
120 μL
200 μL

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Price: $69

Host: Rabbit

Reactivity: H,M,R

Applications: WB,IHC-p,IF,ELISA

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Overview

Synonyms	CTNNA1,Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA2,CAPR,Catenin alpha-2,Alpha N-catenin,Alpha-catenin-related protein
Swissprot	P35221,P26232
Source	Rabbit
Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from the C-terminal region of human Catenin-α E/N
Application	WB,IHC-p,IF,ELISA
Recommended dilution	WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Concentration	1mg/mL
Clonality	Polyclonal

Properties

Cellular localization	Cytoskeleton,actin cytoskeleton,Cytosol,Golgi apparatus,Golgi apparatus,Plasma Membrane,catenin complex,flotillin complex,plasma membrane,Other locations:acrosomal vesicle,cell junction,cell-cell junction,focal adhesion,intercalated disc,intracellular membrane-bounded organelle,lamellipodium,zonula adherens
Tissue specificity	Expressed ubiquitously in normal tissues.
Isotype	IgG
Purification	Affinity purification
Conjugation	Unconjugated
Storage instructions	Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer	PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Background	Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.