CBL Polyclonal Antibody

Uniprot: P22681
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30782

      Synonyms:4732447J05Rik,C CBL,Cas Br M (murine) ecotropic retroviral transforming sequence,Casitas B lineage lymphoma proto oncogene,Casitas B-lineage lymphoma proto-oncogene,CBL 2,cbl,CBL,CBL2,E3 ubiquitin protein ligase CBL,E3 ubiquitin-protein ligase CBL,Oncogene CBL2,Proto oncogene c CBL,Proto-oncogene c-CBL,RGD1561386,RING finger protein 55,RNF55,Signal transduction protein CBL

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

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      Overview

      Synonyms 4732447J05Rik,C CBL,Cas Br M (murine) ecotropic retroviral transforming sequence,Casitas B lineage lymphoma proto oncogene,Casitas B-lineage lymphoma proto-oncogene,CBL 2,cbl,CBL,CBL2,E3 ubiquitin protein ligase CBL,E3 ubiquitin-protein ligase CBL,Oncogene CBL2,Proto oncogene c CBL,Proto-oncogene c-CBL,RGD1561386,RING finger protein 55,RNF55,Signal transduction protein CBL
      Swissprot P22681
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from human Cbl around the non-phosphorylation site of Tyr774.
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder

      Images

      Western Blot analysis of 3T3 cells with Cbl Polyclonal Antibody.

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