CDK4 Polyclonal Antibody

Uniprot : P11802
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-33468

      Synonyms:Cdk 4,cdk4,CDK4 protein,CDK4,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,PSK-J3

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms Cdk 4,cdk4,CDK4 protein,CDK4,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,PSK-J3
      Swissprot P11802
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the N-terminal region of human Cdk4.
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-300, IF 1:50-1:200, ELISA 1:10000-1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

      Images

      Western Blot analysis of MCF7, K562 cells with Cdk4 Polyclonal Antibody.

      Immunohistochemistry of paraffin-embedded Human brain tissue using Cdk4 Polyclonal Antibody at dilution of 1:100.

      Immunofluorescence analysis of Human stomach tissue using Cdk4 Polyclonal Antibody at dilution of 1:200.

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