CDK8 Polyclonal Antibody

Uniprot : P49336
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    <
    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30870

      Synonyms:cdk8,CDK8 protein kinase,CDK8,Cell Division Kinase 8,Cell division protein kinase 8,Cyclin Dependent kinase 8,Cyclin-dependent kinase 8,K35,Mediator complex subunit cdk8,Mediator of RNA polymerase II transcription subunit cdk8,Protein kinase K35

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms cdk8,CDK8 protein kinase,CDK8,Cell Division Kinase 8,Cell division protein kinase 8,Cyclin Dependent kinase 8,Cyclin-dependent kinase 8,K35,Mediator complex subunit cdk8,Mediator of RNA polymerase II transcription subunit cdk8,Protein kinase K35
      Swissprot P49336
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from the N-terminal region of human Cdk8
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

      Images

      Western Blot analysis of 293 cells using Cdk8 Polyclonal Antibody at dilution of 1:500.

      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less

      Browsing History


        People Also Bought