CEP78 Polyclonal Antibody

Uniprot : Q5JTW2
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30885

      Synonyms:5730599I05Rik,C9orf81,Centrosomal protein 78,Centrosomal protein 78kDa,Chromosome 9 open reading frame 81,D030027P05,FLJ12643,FLJ52093,IP63,MGC135040,RP11-336N8.5

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
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      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 5730599I05Rik,C9orf81,Centrosomal protein 78,Centrosomal protein 78kDa,Chromosome 9 open reading frame 81,D030027P05,FLJ12643,FLJ52093,IP63,MGC135040,RP11-336N8.5
      Swissprot Q5JTW2
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from the Internal region of human CEP78
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasmic; centrosome
      Tissue specificity Widely expressed (PubMed:27588451, PubMed:27588452). Expressed in different retinal cell types with higher expression in cone compared to rod cells (at protein level) (PubMed:27588452).
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients.CEP78 (Centrosomal Protein 78) is a Protein Coding gene. Diseases associated with CEP78 include Usher Syndrome and Sensorineural Hearing Loss. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

      Images

      Western Blot analysis of Hela cells with CEP78 Polyclonal Antibody.

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