CLASP1 Polyclonal Antibody

Uniprot: Q7Z460
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    <
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30938

      Synonyms:1700030C23Rik,5730583A19Rik,B130045P17Rik,CLAP1,clasp1,CLIP associating protein 1,CLIP associating protein CLASP1,CLIP-associating protein 1,Cytoplasmic linker associated protein 1,Cytoplasmic linker-associated protein 1,DKFZp686D1968,DKFZp686H2039,FLJ33821,FLJ41222,hOrbit1,KIAA0622,MAST1,MGC131895,mKIAA0622,Multiple asters 1,Multiple asters homolog 1,Protein Orbit homolog 1

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC-p,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 1700030C23Rik,5730583A19Rik,B130045P17Rik,CLAP1,clasp1,CLIP associating protein 1,CLIP associating protein CLASP1,CLIP-associating protein 1,Cytoplasmic linker associated protein 1,Cytoplasmic linker-associated protein 1,DKFZp686D1968,DKFZp686H2039,FLJ33821,FLJ41222,hOrbit1,KIAA0622,MAST1,MGC131895,mKIAA0622,Multiple asters 1,Multiple asters homolog 1,Protein Orbit homolog 1
      Swissprot Q7Z460
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Synthesized peptide derived from the C-terminal region of human CLASP1
      Application WB,IHC-p,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>centrosome. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>spindle. Golgi apparatus>trans-Golgi network. Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
      Isotype IgG
      Purification Affinity purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
      Background Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

      Images

      Western Blot analysis of SH-SY5Y cells using CLASP1 Polyclonal Antibody at dilution of 1:2000.

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