Cleaved PARP1 Monoclonal Antibody

Uniprot : P09874
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22078

      Synonyms:ADP-ribosyltransferase diphtheria toxin-like 1,ADPRT 1,ADPRT,ADPRT1,APOPAIN,ARTD1,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PARP1,PARP1,Poly [ADP-ribose] polymerase 1,Poly ADP ribose polymerase 1,Poly[ADP-ribose] synthase 1,PPOL,SCA1

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H

      Applications: WB,IHC-p,IF

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms ADP-ribosyltransferase diphtheria toxin-like 1,ADPRT 1,ADPRT,ADPRT1,APOPAIN,ARTD1,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PARP1,PARP1,Poly [ADP-ribose] polymerase 1,Poly ADP ribose polymerase 1,Poly[ADP-ribose] synthase 1,PPOL,SCA1
      Swissprot P09874
      Source Mouse
      Reactivity Human
      Immunogen Synthetic Peptide
      Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF
      Recommended dilution WB 1:2000-5000, IHC 1:50-300, IF 1:100-1:300
      Concentration 1mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.
      Clone No. Clone:6K6
      Isotype IgG
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.4
      Background This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

      Images

      Western Blot analysis of Jurkat, cells using Cleaved PARP1 Monoclonal Antibody at dilution of 1:3000.

      Immunohistochemistry of paraffin-embedded Human breast cancer tissue using Cleaved PARP1 Monoclonal Antibody at dilution of 1:200.

      Immunofluorescence analysis of Human liver cancer tissue using Cleaved PARP1 Monoclonal Antibody at dilution of 1:200.

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