Synonyms:CDC like kinase 2,CDC-like kinase 2,CLK 2,CLK kinase,CLK2,Clk2 Scamp3,CLK2,Dual specificity protein kinase CLK2,hCLK 2,hCLK2,Tu52
|Synonyms||CDC like kinase 2,CDC-like kinase 2,CLK 2,CLK kinase,CLK2,Clk2 Scamp3,CLK2,Dual specificity protein kinase CLK2,hCLK 2,hCLK2,Tu52|
|Immunogen||Synthesized peptide derived from the N-terminal region of human CLK2|
|Recommended dilution||WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000|
|Tissue specificity||Endothelial cells.|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.|
|Background||This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants.|
Western Blot analysis of HepG2 cells with CLK2 Polyclonal Antibody.
Western Blot analysis of COLO205 cells with CLK2 Polyclonal Antibody.