CMKLR1 Polyclonal Antibody

Uniprot: Q99788
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    <
    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-30909

      Synonyms:CHEMERINR,Chemokine like receptor 1,Chemokine-like receptor 1,CHEMR23,CMKLR1,CML1,DEZ,G protein coupled receptor ChemR23,G protein coupled receptor DEZ,G-protein coupled receptor ChemR23,G-protein coupled receptor DEZ,Orphan G protein coupled receptor,Orphan G protein coupled receptor Dez,Resolvin E1 receptor,RVER1

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC-p,IF,ELISA

      Lead Time: 2 daysWelcome to order from local distributors.

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      Overview

      Synonyms CHEMERINR,Chemokine like receptor 1,Chemokine-like receptor 1,CHEMR23,CMKLR1,CML1,DEZ,G protein coupled receptor ChemR23,G protein coupled receptor DEZ,G-protein coupled receptor ChemR23,G-protein coupled receptor DEZ,Orphan G protein coupled receptor,Orphan G protein coupled receptor Dez,Resolvin E1 receptor,RVER1
      Swissprot Q99788
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Synthesized peptide derived from the Internal region of human ChemR23
      Application WB,IHC-p,IF,ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
      Concentration 1mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cell membrane.
      Tissue specificity Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

      Images

      Western Blot analysis of 3T3, K562 cells using CMKLR1 Polyclonal Antibody at dilution of 1:1000.

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