EDN3 Polyclonal Antibody

Uniprot : P14138
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14073

      Synonyms:EDN3,EDN3,Endothelin-3,ET 3,ET-3,PPET3,Preproendothelin 3,Preproendothelin-3

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms EDN3,EDN3,Endothelin-3,ET 3,ET-3,PPET3,Preproendothelin 3,Preproendothelin-3
      Swissprot P14138
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human EDN3
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.7 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Secreted.
      Tissue specificity Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. 

      Images

      Immunohistochemistry of paraffin-embedded Human liver cancer tissue using EDN3 Polyclonal Antibody at dilution 1:40

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using EDN3 Polyclonal Antibody at dilution 1:40

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