EGFR Polyclonal Antibody

Uniprot : P00533
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-40283

      Synonyms:Avian erythroblastic leukemia viral (v erb b) oncogene homolog,Cell growth inhibiting protein 40,Cell proliferation inducing protein 61,EGF R,EGFR,EGFR,Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog),Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian),Epidermal growth factor receptor,erb-b2 receptor tyrosine kinase 1,ERBB,ERBB1,Errp,HER1,mENA,NISBD2,Oncogen ERBB,PIG61,Proto-oncogene c-ErbB-1,Receptor tyrosine protein kinase ErbB 1,Receptor tyrosine-protein kinase ErbB-1,SA7,Species antigen 7,Urogastrone,v-erb-b Avian erythroblastic leukemia viral oncogen homolog,wa2,Wa5

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $60

      Host: Rabbit

      Reactivity: H

      Applications: IHC

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Avian erythroblastic leukemia viral (v erb b) oncogene homolog,Cell growth inhibiting protein 40,Cell proliferation inducing protein 61,EGF R,EGFR,EGFR,Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog),Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian),Epidermal growth factor receptor,erb-b2 receptor tyrosine kinase 1,ERBB,ERBB1,Errp,HER1,mENA,NISBD2,Oncogen ERBB,PIG61,Proto-oncogene c-ErbB-1,Receptor tyrosine protein kinase ErbB 1,Receptor tyrosine-protein kinase ErbB-1,SA7,Species antigen 7,Urogastrone,v-erb-b Avian erythroblastic leukemia viral oncogen homolog,wa2,Wa5
      Swissprot P00533
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant Human Epidermal growth factor receptor protein
      Application IHC(Detection kit: E-IR-R213)
      Recommended dilution IHC 1:100-1:200
      Concentration 0.57mg/mL

      Properties

      Cellular localization Secreted and Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus membrane. Endosome. Endosome membrane. Nucleus.
      Tissue specificity Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
      Isotype IgG
      Purification Affinity Purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
      Background EGFR,also named as ERBB1,is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12,encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression,including cell proliferation,apoptosis,angiogenesis,and metastatic spread. Mutations in this gene are associated with lung cancer.

      Images

      Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using EGFR Polyclonal Antibody at dilution of 1:100

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