FLT3 Polyclonal Antibody

Uniprot : P36888
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14621

      Synonyms:CD 135,CD135,CD135 antigen,Fetal liver kinase 2,FL cytokine receptor,Flk 2,Flk2,Flt 3,FLT-3,Flt3,FLT3,FMS like tyrosine kinase 3,Fms related tyrosine kinase 3,Fms-like tyrosine kinase 3,Growth factor receptor tyrosine kinase type III,Ly-72,OTTHUMP0000004234,Receptor type tyrosine protein kinase FLT3,Stem cell tyrosine kinase 1,Stk 1,STK-1,Stk1,Tyrosine protein kinase receptor FLT3,Tyrosine-protein kinase receptor FLT3

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CD 135,CD135,CD135 antigen,Fetal liver kinase 2,FL cytokine receptor,Flk 2,Flk2,Flt 3,FLT-3,Flt3,FLT3,FMS like tyrosine kinase 3,Fms related tyrosine kinase 3,Fms-like tyrosine kinase 3,Growth factor receptor tyrosine kinase type III,Ly-72,OTTHUMP0000004234,Receptor type tyrosine protein kinase FLT3,Stem cell tyrosine kinase 1,Stk 1,STK-1,Stk1,Tyrosine protein kinase receptor FLT3,Tyrosine-protein kinase receptor FLT3
      Swissprot P36888
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human FLT3
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:200-1:1000, IHC 1:25-1:100
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Membrane.
      Tissue specificity Bone marrow cells.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

      Images

      Western Blot analysis of Lovo and 231 cell using FLT3 Polyclonal Antibody at dilution of 1:240

      Immunohistochemistry of paraffin-embedded Human thyroid cancer using FLT3 Polyclonal Antibody at dilution of 1:30

      Immunohistochemistry of paraffin-embedded Human liver cancer using FLT3 Polyclonal Antibody at dilution of 1:30

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