GSK3 beta Polyclonal Antibody

Uniprot : P49841
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-12495

      Synonyms:Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,GSK 3 beta,GSK-3 beta,GSK3B,GSK3B,GSK3beta isoform,Serine/threonine-protein kinase GSK3B

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,GSK 3 beta,GSK-3 beta,GSK3B,GSK3B,GSK3beta isoform,Serine/threonine-protein kinase GSK3B
      Swissprot P49841
      Source Rabbit
      Reactivity Human ,Mouse ,Rat
      Immunogen Synthetic peptide of human GSK3B
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:500-1:2000
      Concentration 0.6 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
      Tissue specificity Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.

      Images

      polyclonal antibody-Elabscience

      Western Blot analysis of Human small intestine stromal cancer tissue using GSK3 beta Polyclonal Antibody at dilution of 1:100

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