GSK3 beta Polyclonal Antibody

Uniprot : P49841
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      Catalog number:E-AB-63558

      Synonyms:Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,GSK 3 beta,GSK-3 beta,GSK3B,GSK3B,GSK3beta isoform,Serine/threonine-protein kinase GSK3B

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H

      Applications: WB

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,GSK 3 beta,GSK-3 beta,GSK3B,GSK3B,GSK3beta isoform,Serine/threonine-protein kinase GSK3B
      Swissprot P49841
      Source Rabbit
      Reactivity Human
      Immunogen A synthetic peptide of human GSK3B
      Application WB(Detection kit: E-IR-R304)
      Recommended dilution WB 1:500 - 1:2000
      Concentration 1mg/ml
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
      Tissue specificity Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
      Background The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

      Images

      Western blot analysis of extracts of various cell lines with GSK3 beta Polyclonal Antibody

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