IL12B Monoclonal Antibody (AN200248P)

Name: IL12B Monoclonal Antibody
Brand: Elabscience
SKU: AN200248P
Price: 320.0 USD
Availability: InStock

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	100μL	$ 320.00	- +

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Verified Samples	Verified Samples in IHC: Mouse spleen
Dilution	IHC-P 1:100-1:500
Isotype	Mouse IgG1
Host	Mouse
Reactivity	Mouse
Applications	IHC-P
Clonality	Monoclonal
Immunogen	Recombinant Mouse IL12B Protein
Abbre	IL12B
Synonyms	CLMF, CLMF p, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), IL 12B, IL-12 p40, IL-12 p70, IL-12 subunit p, IL-12 subunit p40, IL-12/IL-23 p, IL-12/IL-23 p40, IL-12B, IL12, IL12 p, IL12 p70, Il12b, Interleukin-12 subunit beta, NK cell Stimulating Factor Chain, NK cell Stimulating Factor Chain 2, NK cell stimulatory factor chain, NK cell stimulatory factor chain 2, NKSF, NKSF2, p40
Swissprot	P43432
Concentration	1 mg/mL
Buffer	0.2 μm filtered solution in PBS
Purification Method	Protein A
Research Areas	Cancer, Immunology
Clone	A1102
Conjugation	Unconjugated
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Shipping	Ice bag
background	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.1 PublicationAssociates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.