IRAK1BP1 Polyclonal Antibody

Uniprot : Q5VVH5
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    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14168

      Synonyms:ActA binding protein 3,AIP70,Interleukin 1 receptor associated kinase 1 binding protein 1,IRAK1-binding protein 1,Signaling molecule that associates with Pelle-like kinase,SIMPL

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms ActA binding protein 3,AIP70,Interleukin 1 receptor associated kinase 1 binding protein 1,IRAK1-binding protein 1,Signaling molecule that associates with Pelle-like kinase,SIMPL
      Swissprot Q5VVH5
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human IRAK1BP1
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:200-1:1000, IHC 1:50-1:200
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasmic and Nuclear
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

      Images

      Western Blot analysis of Human testis tissue using IRAK1BP1 Polyclonal Antibody at dilution of 1:350

      Immunohistochemistry of paraffin-embedded Human brain using IRAK1BP1 Polyclonal Antibody at dilution of 1:30

      Immunohistochemistry of paraffin-embedded Human colon cancer using IRAK1BP1 Polyclonal Antibody at dilution of 1:30

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