LRRK2 Polyclonal Antibody

Uniprot : Q5S007
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14196

      Synonyms:augmented in rheumatoid arthritis 17,AURA17,Dardarin,Leucine rich repeat kinase 2,leucine rich repeat serine threonine protein kinase 2,Leucine-rich repeat serine/threonine-protein kinase 2,LRRK 2,LRRK2,LRRK2,PARK 8,PARK8,RIPK7,ROCO 2,ROCO2

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms augmented in rheumatoid arthritis 17,AURA17,Dardarin,Leucine rich repeat kinase 2,leucine rich repeat serine threonine protein kinase 2,Leucine-rich repeat serine/threonine-protein kinase 2,LRRK 2,LRRK2,LRRK2,PARK 8,PARK8,RIPK7,ROCO 2,ROCO2
      Swissprot Q5S007
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human LRRK2
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Membrane. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Endosome. Lysosome. Mitochondrion outer membrane. Mitochondrion inner membrane. Mitochondrion matrix. Predominantly associated with intracytoplasmic vesicular and membranous structures (By similarity). Localized in the cytoplasm and associated with cellular membrane structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes.
      Tissue specificity Expressed in the brain. Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

      Images

      Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LRRK2 Polyclonal Antibody at dilution 1:30

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using LRRK2 Polyclonal Antibody at dilution 1:30

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