MCM8 Polyclonal Antibody

Uniprot : Q9UJA3
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14215

      Synonyms:C20orf154,dJ967N21.5,DNA helicase MCM8,DNA replication licensing factor MCM8,MCM8,MCM8,MGC119522,MGC119523,MGC12866,MGC4816,Minichromosome maintenance 8,Minichromosome maintenance complex component 8,REC

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms C20orf154,dJ967N21.5,DNA helicase MCM8,DNA replication licensing factor MCM8,MCM8,MCM8,MGC119522,MGC119523,MGC12866,MGC4816,Minichromosome maintenance 8,Minichromosome maintenance complex component 8,REC
      Swissprot Q9UJA3
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human MCM8
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:200-1:1000
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Localizes to nuclear foci and colocalizes with RAD51.
      Tissue specificity Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

      Images

      Western Blot analysis of Jurkat cell using MCM8 Polyclonal Antibody at dilution of 1:300

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